Table 4.
Univariate and Multivariable analysis results for the association of underlying disease and drug history with in-hospital death in patients with COVID-19 in different age and sex subgroups
| Variables | Univariate | Multivariable | ||
|---|---|---|---|---|
| RR (95% CI) | P | RR (95% CI) | P | |
| Males over 55 years old** | ||||
| Hypertension | ||||
| No | 1 | 1 | - | |
| Yes | 1.34(1.03-1.74) | 0.029* | 1.62(1.22-2.14) | 0.001* |
| Taking Beta blocker | ||||
| No | 1 | 1 | ||
| Yes | 0.77(0.51-1.14) | 0.200 | 0.68(0.46-1.02) | 0.063 |
| Taking ACEi or ARB | ||||
| No | 1 | 1 | ||
| Yes | 0.89(0.66-1.02) | 0.446 | 0.74(0.54-1.01) | 0.063 |
| Females under 65 years old | ||||
| Coronary Artery Disease | ||||
| No | 1 | 1 | ||
| Yes | 3.01(1.55-5.84) | 0.001* | 2.40(1.24-4.64) | 0.009* |
| Taking Atorvastatin | ||||
| No | 1 | 1 | ||
| Yes | 2.45(1.29-4.67) | 0.006* | 1.74(0.90-3.37) | 0.096 |
| Taking ACEi or ARB | ||||
| No | 1 | 1 | ||
| Yes | 2.16(1.18-4.03) | 0.012* | 1.72(0.92-3.20) | 0.085 |
| Females over 65 years old | - | |||
| Hypertension | ||||
| No | 1 | 1 | ||
| Yes | 1.10(0.72-1.70) | 0.643 | 1.16(0.912-1.75) | 0.086 |
| Taking ACEi or ARB | ||||
| No | 1 | 1 | ||
| Yes | 0.521(0.32-0.83) | 0.007* | 0.27 (0.17-0.41) | <0.001* |
| Chronic kidney Disease | ||||
| No | 1 | 1 | ||
| Yes | 1.51(0.969-2.33) | 0.068 | 1.34(0.945-2.39) | 0.067 |
CI: confidence interval. *P<0.05 was considered statistically significant. **All variables were excluded in the final model of the subgroup of males under 55 years old. ACEi: Angiotensin Converting Enzyme Inhibitor; ARB: Angiotensin Receptor Blocker.