Table 2.
List of Patent for various hydrogel formulation.
| S. No. | Patent No./Country | Title | Disease/Problem | Details |
|---|---|---|---|---|
| 1 | US10799696B2 United States |
Polymer formulations for nasolacrimal stimulation | Dry eye | The hydrogel formulation (prepared by a UV crosslinking process) permits electrical stimulation of the lacrimal gland, nasal or sinus tissue to ↑ production of tear and to treat dry eye |
| 2 | US20200085733A1 United States |
Hypotonic hydrogel formulations for enhanced transport of active agents at mucosal surfaces | Administered into vagina or colorectum for diagnostic, prophylactic and therapeutic purpose | An aqueous polymeric hydrogel (poloxamers) used as a barrier by forming plug and/or used for the delivery to a mucosal/epithelial surface for therapeutic, preventive, diagnostic or nutraceutical purpose |
| 3 | US20200114010A1 United States |
Non-injectable hydrogel formulations for smart release | The formulation contains anti-inflammatories, anti-infectives, or other therapeutic, prophylactic, or diagnostic agents that can be administered orally to produce desire action | A non-injectable formulation/formulation for instillation, with self-assembling hydrogels designed of gelators, in the form of capsules, tablets, oral suspensions, rectal or vaginal suppositories, enemas, and inserts |
| 4 | US20180023049A1 United States |
Synthetic peptide hydrogel formulations for use as extracellular matrix | Cell culture experimentation | Synthetic peptide hydrogel solutions having a pH level of about 3.5/˂ and having a tonicity within an isotonic osmolality range |
| 5 | US20200360281A1 United States |
A thermo-responsive hydrogel for intertumoral administration as a treatment in solid tumor cancers | Intra tumoral treatment of solid cancer | Injectable thermo-responsive hydrogel forming a chitosan and genipin interpenetrating scaffold by crosslinking can effectively incorporate chemotherapeutic drugs without any loss of thermo-responsiveness |
| 6 | WO2019067406A1 WIPO (PCT) |
Biomimetic, moldable, self-assembled cellulose silica-based trimeric hydrogels and their use as viscosity modifying carriers in industrial applications | Use as low-cost and safe carriers and aqueous viscosity modifiers in various industrial and medical applications | A moldable, cellulose silica-based hydrogels which is fully scalable |
| 7 | US20190127726A1 United States |
Delivering enzyme using an injectable hydrogel depot | To deliver enzymes | A delivery system for carrying an injectable enzyme hydrogel formulation consisting of an enzyme together with other components |
| 8 | WO2017152112A2 WIPO (PCT) |
Hydrogel systems for skeletal interfacial tissue regeneration applied to epiphyseal growth plate repair | It can be applied through numerous different modalities depending on the nature of the physical injury | Biomaterials, systems, and methods for guiding regeneration of an epiphyseal growth plate or similar interfacial tissue structures |
| 9 | JP6293254B2 Japan |
Silicone hydrogel lens with crosslinked hydrophilic coating | Contact lens | Coated silicone hydrogel contact lens containing a surface coating of silicone hydrogel and a non-silicone hydrogel which is a crosslinked polymer consisting of one or more cross-linkable materials and a crosslinked carboxyl-containing polymer material |
| 10 | CN105209016B China |
Biocompatible hydrogel polymer matrices for cell delivery | A solid support that is beneficial for cell viability and functionality | Biocompatible hydrogel polymer matrices, bioabsorbable and releases cells at the target site, thus permitting controlled delivery |
| 11 | US20200299627A1 United States |
Crosslinked hydrogel compositions for regulating states of encapsulated cancer cells | Method of regulating the state of cancer cells | A system composed of a crosslinked poly alkylene glycol based hydrogel, systems comprising a number of cancer cells in contact with the culture media and encapsulated inside the hydrogel, and the method of making and using the same |
| 12 | JP2020514500A Japan |
Antibacterial polymer and antibacterial hydrogel | Antimicrobial polymers and antimicrobial hydrogels | An antimicrobial hydrogel containing a substituted C5-C15 alkyl; a polyethyleneimine-alkyl-polyethylene glycol methacrylate implant ratio ranging from 1:1:1 to 1:20:20 and a method of forming the same, providing a device having a surface coating the antimicrobial hydrogel as well |
| 13 | EP2801377B1 European Patent Office |
Hydrogel comprising cells for local release of growth factors to mediate motor recovery after stroke | Hydrogel comprising cells that provide a sustained release of brain derived neurotrophic factor (BDNF) for improving recovery of a mammal after cerebral ischemia | Method of administering a therapeutically effective amount of BDNF to the infarct cavity in the mammalian brain for the treatment of cerebral ischemia |
| 14 | US20190282699A1 United States |
Thiolated hyaluronan-based hydrogels crosslinked using oxidized glutathione | Hydrogel comprising the therapeutic agent, carboxymethylated hyaluronan and thiolated gelatin | Methods, compositions and kits linking to hyaluronan based matrices with oxidized glutathione as a crosslinking agent |
| 15 | WO2021019562A2 WIPO (PCT) |
Bioengineered formulation, process for preparing and implementations thereof | Bioengineered formulation for corneal applications | A bioengineered formulation consisting of a modified collagen peptide and hyaluronic acid further, encompassing stem cells/exosomes or combinations therefrom |
| 16 | US10632070B2 United States |
Hydrogel toxin-absorbing or binding nanoparticles | For ↓ or neutralizing the effect of a toxin, or for treating or preventing an infection by a microbe that produces a toxin, in a subject | Polymeric hydrogel formulation infused with a toxin-absorbing or binding nanoparticle |
| 17 | CN105979969B China |
Topical compositions and methods of using the same | A topical pharmaceutical composition | A topical composition comprises a nitric oxide releasing active pharmaceutical ingredient mixed with a hydrophilic and a hydrophobic composition, in which the nitric oxide releasing active pharmaceutical ingredient encompasses a diazeniumdiolate (A nitric oxide releasing compound of a functional group) |
| 18 | JP6309458B2 Japan |
Silicone hydrogel comprising N-vinylamide and hydroxyalkyl (meth) acrylate or (meth) acrylamide | Silicone hydrogel soft contact lenses provide improved oxygen permeability compared to soft lenses made from non-silicone materials | A silicone hydrogel comprising n-vinylamide and hydroxyalkyl (meth) acrylate/(meth) acrylamide |
| 19 | US10620456B2 United States |
Increased stiffness center optic in soft contact lenses for astigmatism correction | Contact lenses for the correction of astigmatism | Contact lenses having a higher stiffness in the central optic zone for the correction of astigmatic refractive errors as well as possible higher order aberrations created by corneal geometry |
| 20 | JP6143269B2 Japan |
Self-assembled composite ultra-small peptide polymer hydrogel | Topical agents for wound healing, as well as for delivering pharmaceuticals and other bioactive agents/components | A method for fabricating composite hydrogels, as implants/injectables that encourage tissue regeneration and as topical agents for wound healing to deliver pharmaceuticals and other bioactive agents components |
| 21 | US9937254B2 United States |
Water-soluble supramolecular complexes | The complexes are useful in a variety of pharmaceutical and cosmetic products and may be combined with an effective amount of a cosmetic, medicament, or diagnostic in a solid dosage form | Water-soluble supramolecular complexes formed when combined with water, form a transparent thermo-reversible hydrogel/solution that may be repeatedly hydrated and dehydrated for sparely soluble and insoluble pharmaceutical agents, exhibits ↑ gelling efficiency, ↑ solubility and/or stability |
| 22 | EP2708224A1 European Patent Office |
Biocompatible hydrogel polymer formulations for the controlled delivery of biomolecules | A biocompatible, bioabsorbable hydrogel polymer that releases the therapeutic agent at a target site, avoiding systemic exposure in a controlled delivery | The kits including at least one nucleophilic compound/monomer unit, minimum one electrophilic compound/monomer unit, and at least one drug. Further, the therapeutic agent such as a protein or other biomolecule is capable of gelling in vivo |
| 23 | JP2017527422A Japan |
Composite materials for tissue repair | Composite materials and methods which restore lost soft tissue volume and promote soft tissue regeneration | A structural framework composite having a polymeric fiber component covalently bonded to a hydrogel material possessing ↑ properties |
| 24 | US20190343761A1 United States |
Antibiotic formulations for lower back pain | Injectable, thermo gelling hydrogel formulations to relieve and/or treat low back pain | A thermosensitive hydrogel, consisting of an effective amount of an antibiotic, a radio-contrast agent, and at least 1 pharmaceutically acceptable excipient |
| 25 | US20170360912A1 United States |
Chitosan-based hydrogel and applications thereof. | Chitosan-based hydrogel for medical and cosmetic treatments | flowable formulation and becomes a gel after a gelation time (depending on temperature) just immediately after preparation, containing chitosan, 0.4 M of sodium hydrogen carbonate (SHC), and a weak base different from the SHC |
| 26 | US10842743B2 United States |
Modified hyaluronic acid hydrogels and proteins for the time-controlled release of biologic agents | Composition as a liquid capable of in situ formation of a hyaluronic acid-based hydrogel for treating a subject suffering from tumor(s) | Discloses the hyaluronic acid-based hydrogels, solutions for preparing same, and methods relating to this. It includes properties such as extended release, self-resorption of drug, and/or ↓ degradation, denaturation, and/or functional inactivation of active agents |
| 27 | US9211107B2 United States |
Ruggedized ultrasound hydrogel insert | A ruggedized hydrogelproduct suitable for use in medical applications where sterile components are required | It contains a gel component, water for hydrating it, and minimum one free radical absorber component that has the capacity to absorb free radicals produced during the sterilization of the hydrogel through a high-energy sterilization procedure and can survive the effects of high-energy sterilization procedures, without substantial structural degradation |
| 28 | TWI558414B Taiwan |
Thermosensitive injectable hydrogel for drug delivery | Heat-sensitive injectable hydrogels for drug delivery for delivering anti-cancer drugs | A heat-sensitive injectable hydrogel system based on hyaluronic acid and a copolymer of polyethylene oxide and poly oxypropylene, (having a gel formation temperature of 30 °C to 37 °C), providing an efficient drug delivery system that ↑ the therapeutic efficacy of the drug |
| 29 | JP6066237B2 Japan |
Antibacterial ophthalmic contact lenses | Antibacterial ophthalmic devices made of hydrogel and epsilon polylysine (εPLL) | It comprises a hydrogel and at least 5μg εPLL bonded non-covalently to the hydrogel, the contact lens and the packaging solutions |
| 30 | EP3151872B1 European Patent Office |
Wound dressing | A stimuli responsive wound dressing application against a wound site of a human or animal body | A wound dressing containing a lyophilized hyaluronic acid hydrogel and a number of implanted devices within hydrogel, each device includes chitosan and hypromellose where the formulation absorbs water and/or exudates and maintain a moist wound site which encourages angiogenesis and wound healing |
| 31 | EP3708167A1 European Patent Office |
Immunomodulating treatments of body cavities | A combination medicaments for use in treatment of a cancer of an internal body cavity including urinary tract cancer, meant for local administration in a thermo-reversible hydrogel composition | A biocompatible hydrogel composition incorporating the combination of at least 2 immunomodulatory agents, where one or more of the therapeutic agents are embedded inside, and slowly released from it |
| 32 | WO2019221559A1 WIPO (PCT) |
Microneedle adhesive patch based on hydrogel formulation | A microneedle patch that can be utilized for transdermal drug delivery to promote wound regeneration shows brilliant tissue adhesion, biocompatibility, and biodegradability | It comprises a 1st hydrogel layer with mussel adhesive protein and hyaluronic acid and 2nd hydrogel layer with silk fibroin, and a method for manufacturing it |
| 33 | WO2020036526A1 WIPO (PCT) |
A biphasic hydrogel formulation and methods of production and use thereof | Creates an environment that relieves or encourages the healing process for the treatment of insect bites, erythema, pruritus, sunburn, acne, dry skin or callus | A hydrogel patch where a biphasic formulation is organized that encompassing a liquid layer externally and an elastic hydrogel in which the water formed on the surface of the elastic gel is physically cooling the skin by evaporation and give a 1st boost of the drug directly when placing on the skin |
| 34 | US20200246472A1 United States |
Hydrogel-forming composition for controlled release | Drug delivery systems (injectable biogel) | Peptide hydrogelators capable of forming hydrogels as carriers of active ingredients/biological materials and act as sustained/controlled release systems |
| 35 | AU2015374022B2 Australia |
Polyfunctional radical scavenger hydrogel formulation | Providing extended protection of the extracellular space within a wound site | The polyfunctional radical scavenger hydrogel formulation, A portion of the 1st radical scavenger included with the formulation and/or 2nd radical scavenger included within the formulation either in dissolved, suspended and/or bonded to a polymer of the hydrogel |
| 36 | US10471181B2 United States |
Fiber-hydrogel composite surgical meshes for tissue repair | A surgical scaffold device for reducing foreign body response, managing tissue-materials interface, and improving the integration of the surgical mesh with the surrounding tissue of a subject | It disclose a composition and methods for a hydrogel/ nanofiber-hydrogel composite integrated with a surgical scaffold or mesh |