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. 2021 Nov 5;7(4):199. doi: 10.3390/gels7040199

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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The MMP-cleavable peptides-based hydrogels for bone regeneration in vivo. (a) The MMP-cleavable peptides-based hydrogels were used to deliver growth factors (BMP-2) to promote bone healing [125]. Statistical significance (p < 0.05): (*) compared to empty defect, (#) compared to the same hydrogel formulation without BMP-2, and (+) compared to 3 wt.% hydrogels with and without BMP-2. Reprinted with permission from Copyright © 2014 Elsevier B.V. (b) The MMP-cleavable peptides-based hydrogels with adhesive peptide (GFOGER) enhanced bone regeneration in challenging defects [8]. Reprinted with permission from Copyright © 2014 Elsevier Ltd. (c) The MMP-cleavable peptides-based hydrogels were used as tissue-engineered periosteum (TEP) to coordinate bone repair via recruitment and support of host neurovasculature [30]. Reprinted with permission from Copyright © 2020 Elsevier Ltd. (d) The MMP-cleavable peptides-based hydrogels were explored for pro-angiogenic peptide drug delivery to increase vascularization in vivo [127]. Reprinted with permission from Copyright © 2015 Elsevier B.V.