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The independent variables and their levels low (0), medium (−1), and high (+1) used in optimization α-MNG-PLGA NPs using experimental design.
| Independent Variables | Level Used (Coded) | ||
|---|---|---|---|
| Low (−1) | Medium (0) | High (+1) | |
| X1: Polymer concentration (% w/v) | 2.5 | 3.00 | 3.50 |
| X2: Surfactant concentration (% w/v) | 1.00 | 1.75 | 2.50 |
| X3: Sonication time (min) | 4 | 8 | 12 |
| Dependent variables | |||
| Y1: Particle size (nm) | Minimize | ||
| Y2: PDI | Minimize | ||
| Y3: Entrapment efficiency (%) | Maximize | ||
