Table 2.
The analyzed responses in experimental design for the preparation of α-MNG-PLGA NPs.
| Formulation Code | Independent Variables | Responses | ||||
|---|---|---|---|---|---|---|
| X1 (% w/v) | X2 (% w/v) | X3 (min) | Y1 (nm) | Y2 | Y3 (%) | |
| * NP1 | 3.00 | 1.75 | 8.00 | 176 ± 19.04 | 0.205 ± 0.02 | 78 ± 8.67 |
| NP2 | 2.50 | 1.00 | 8.00 | 187 ± 24.12 | 0.302 ± 0.03 | 68 ± 6.12 |
| * NP3 | 3.00 | 1.75 | 8.00 | 171 ± 15.67 | 0.210 ± 0.04 | 79 ± 9.34 |
| NP4 | 3.50 | 1.75 | 12.00 | 167 ± 13.45 | 0.233 ± 0.02 | 83 ± 7.98 |
| * NP5 | 3.00 | 1.75 | 8.00 | 172 ± 21.81 | 0.206 ± 0.01 | 74.9 ± 6.80 |
| NP6 | 3.00 | 2.50 | 12.00 | 125 ± 10.01 | 0.276 ± 0.05 | 75 ± 10.07 |
| NP7 | 2.50 | 1.75 | 4.00 | 230 ± 33.76 | 0.281 ± 0.01 | 51 ± 9.23 |
| NP8 | 3.50 | 1.00 | 8.00 | 172 ± 11.93 | 0.215 ± 0.03 | 83 ± 9.65 |
| NP9 | 3.00 | 2.50 | 4.00 | 198 ± 19.62 | 0.306 ±0.04 | 72 ± 11.92 |
| NP10 | 2.50 | 2.50 | 8.00 | 167 ± 17.12 | 0.321 ± 0.02 | 53 ± 4.47 |
| * NP11 | 3.00 | 1.75 | 8.00 | 173 ± 16.02 | 0.199 ± 0.01 | 76 ± 11.21 |
| NP12 | 3.50 | 2.50 | 8.00 | 162 ± 14.03 | 0.268 ± 0.02 | 90 ± 12.76 |
| NP13 | 3.00 | 1.00 | 4.00 | 194 ± 24.98 | 0.203 ± 0.07 | 74 ± 9.67 |
| NP14 | 3.50 | 1.75 | 4.00 | 174 ± 17.54 | 0.222 ± 0.09 | 81 ± 8.78 |
| NP15 | 3.00 | 1.00 | 12.00 | 166 ± 19.32 | 0.312 ± 0.06 | 84 ± 7.43 |
| * NP16 | 3.00 | 1.75 | 8.00 | 172 ± 21.78 | 0.212 ± 0.03 | 77 ± 9.56 |
| NP17 | 2.50 | 1.75 | 12.00 | 132 ± 12.67 | 0.321 ± 0.05 | 61 ± 7.12 |
X1: Polymer concentration (% w/v); X2: Surfactant concentration (% w/v); X3: Sonication time (min); Y1: Particle size (nm); Y2: PDI; Y3: Entrapment efficiency (%). * Replicas.