Table 1.
The analysis of the MYCN gene (table has been reproduced from the NCBI provided data https://www.ncbi.nlm.nih.gov/gene/4613, accessed on 20 June 2021.).
| Type | Start | Stop | Strand | Comment |
|---|---|---|---|---|
| source | 1 | 6455 | 5′→3′ | /gene = MYCN /gene_synonym = MYCN-AS1; N-CYM; NCYM; NYCM /organism = Homo sapiens /mol_type = genomic DNA /db_xref = taxon:9606 /chromosome = 2 |
| gene | <1C | 1884 | 3′→5′ | /note = MYCN opposite strand; Derived by automated computational analysis /db_xref = GeneID:10408 /db_xref = HGNC:HGNC:16911 /db_xref = MIM:605374 |
| ncRNA | <425C 983C |
548 1136 |
3′→5′ | /ncRNA_class = lncRNA /product = MYCN opposite strand, transcript variant 1 /transcript_id = NR_110230.2 |
| ncRNA | <425C 983C |
548 1884 |
3′→5′ | /ncRNA_class = lncRNA /gene = MYCNOS /gene_synonym = MYCN-AS1; N-CYM; NCYM; NYCM /product = MYCN opposite strand, transcript variant 3 /transcript_id = NR_161163.1 |
| ncRNA | 425C 983C |
548 1136 |
3′→5′ | /ncRNA_class = lncRNA /gene = MYCNOS /gene_synonym = MYCN-AS1; N-CYM; NCYM; NYCM /product = MYCN opposite strand, transcript variant 2 /transcript_id = NR_161162.1 |
| mRNA | 1 1399 4944 |
504 2305 6455 |
5′→3′ | /gene_synonym = bHLHe37; MODED; N-myc; NMYC; ODED /product = MYCN proto-oncogene, bHLH transcription factor, transcript variant 1 /transcript_id = NM_001293228.2 |
| mRNA | 1 1399 4944 |
194 2305 6455 |
5′→3′ | /gene = MYCN /gene_synonym = bHLHe37; MODED; N-myc; NMYC; ODED /product = MYCN proto-oncogene, bHLH transcription factor, transcript variant 2 /transcript_id = NM_005378.6 /db_xref = Ensembl:ENST00000281043.4 |
| mRNA | 1 1399 4944 |
194 2305 6455 |
5′→3′ | /gene = MYCN /gene_synonym = bHLHe37; MODED; N-myc; NMYC; ODED /product = MYCN proto-oncogene, bHLH transcription factor, transcript variant 2 /transcript_id = NM_001293233.2 |
| mRNA | 1 4944 |
194 6455 |
/gene = MYCN /gene_synonym = bHLHe37; MODED; N-myc; NMYC; ODED /product = MYCN proto-oncogene, bHLH transcription factor, transcript variant 3 /transcript_id = NM_001293231.2 |
|
| CDS | 38 4944 |
194 5548 |
5′→3′ | /gene = MYCN /gene_synonym = bHLHe37; MODED; N-myc; NMYC; ODED /note = isoform 2 is encoded by transcript variant 3; /codon_start = 1 /product = N-myc proto-oncogene protein isoform 2 /protein_id = NP_001280160.1 /db_xref = CCDS:CCDS86823.1 /translation=MRGAPGNCVGAEQALARRKRAQTVAIRGHPRPPGPPGDTRAESPPDPLQSAGDDEDDEEEDEEEEIDVVTVEKRRSSSNTKAVTTFTITVRPKNAALGPGRAQSSELILKRCLPIHQQHNYAAPSPYVESEDAPPQKKIKSEASPRPLKSVIPPKAKSLSPRNSDSEDSERRRNHNILERQRRNDLRSSFLTLRDHVPELVKNEKAAKVVILKKATEYVHSLQAEEHQLLLEKEKLQARQQQLLKKIEHARTC |
| CDS | 38 1399 |
194 1580 |
5′→3′ | /gene = MYCN /gene_synonym = bHLHe37; MODED; N-myc; NMYC; ODED /note = isoform 3 is encoded by transcript variant 2; /codon_start = 1 /product = N-myc proto-oncogene protein isoform 3 /protein_id = NP_001280162.1 /db_xref = GeneID:4613 /db_xref = HGNC:HGNC:7559 /db_xref = MIM:164840 /translation=MRGAPGNCVGAEQALARRKRAQTVAIRGHPRPPGPPGDTRAESPPDPLQSAGVLEVGAGPRLPRPPREGSTPGIKTNGAERSPQSPAGRRADAELLHVHHAGHDLQEPRPRV |
| CDS | 1516 4944 |
2305 5548 |
5′→3′ | /gene = MYCN /gene_synonym = bHLHe37; MODED; N-myc; NMYC; ODED /note = isoform 1 is encoded by transcript variant 2; /codon_start = 1 /product = N-myc proto-oncogene protein isoform 1 /protein_id = NP_005369.2 /db_xref = CCDS:CCDS1687.1 /db_xref = Ensembl:ENSP00000281043.3 /db_xref = GeneID:4613 /db_xref = HGNC:HGNC:7559 /db_xref = MIM:164840 /translation=MPSCSTSTMPGMICKNPDLEFDSLQPCFYPDEDDFYFGGPDSTPPGEDIWKKFELLPTPPLSPSRGFAEHSSEPPSWVTEMLLENELWGSPAEEDAFGLGGLGGLTPNPVILQDCMWSGFSAREKLERAVSEKLQHGRGPPTAGSTAQSPGAGAASPAGRGHGGAAGAGRAGAALPAELAHPAAECVDPAVVFPFPVNKREPAPVPAAPASAPAAGPAVASGAGIAAPAGAPGVAPPRPGGRQTSGGDHKALSTSGEDTLSDSDDEDDEEEDEEEEIDVVTVEKRRSSSNTKAVTTFTITVRPKNAALGPGRAQSSELILKRCLPIHQQHNYAAPSPYVESEDAPPQKKIKSEASPRPLKSVIPPKAKSLSPRNSDSEDSERRRNHNILERQRRNDLRSSFLTLRDHVPELVKNEKAAKVVILKKATEYVHSLQAEEHQLLLEKEKLQARQQQLLKKIEHARTC |
| misc_feature | 1570 | 1656 | 5′→3′ | /gene = MYCN /gene_synonym = bHLHe37; MODED; N-myc; NMYC; ODED /note = propagated from UniProtKB/Swiss-Prot (P04198.2); Region: Interactio nwith AURKA./evidence=ECO:0000269|PubMed:27837025 |
| misc_feature | 1696 | 1782 | 5′→3′ | /gene = MYCN /gene_synonym = bHLHe37; MODED; N-myc; NMYC; ODED /note = propagated from UniProtKB/Swiss-Prot (P04198.2); Region: Interaction with AURKA and FBXW7./evidence=ECO:0000269|PubMed:27837025 |
| misc_feature | 2296 | 2298 | 5′→3′ | /gene = MYCN /gene_synonym = bHLHe37; MODED; N-myc; NMYC; ODED /note = Phosphoserine, by CK2./evidence=ECO:0000269|PubMed:1425701; propagated from UniProtKB/Swiss-Prot (P04198.2); phosphorylation site |
| misc_feature | 2302 | 2304 | 5′→3′ | /gene = MYCN /gene_synonym = bHLHe37; MODED; N-myc; NMYC; ODED /note = Phosphoserine, by CK2./evidence=ECO:0000269|PubMed:1425701; propagated from UniProtKB/Swiss-Prot (P04198.2); phosphorylation site |
| misc_feature | 5450 | 5515 | 5′→3′ | /gene = MYCN /gene_synonym = bHLHe37; MODED; N-myc; NMYC; ODED /note = propagated from UniProtKB/Swiss-Prot (P04198.2); Region: Leucine-zipper |
| CDS | 1516 4944 |
2305 5548 |
5′→3′ | /gene = MYCN/ gene_synonym = bHLHe37; MODED; N-myc; NMYC; ODED /note = isoform 1 is encoded by transcript variant 1; /codon_start = 1 /product = N-myc proto-oncogene protein isoform 1/protein_id = NP_001280157.1 /db_xref = CCDS:CCDS1687.1 /translation=MPSCSTSTMPGMICKNPDLEFDSLQPCFYPDEDDFYFGGPDSTPPGEDIWKKFELLPTPPLSPSRGFAEHSSEPPSWVTEMLLENELWGSPAEEDAFGLGGLGGLTPNPVILQDCMWSGFSAREKLERAVSEKLQHGRGPPTAGSTAQSPGAGAASPAGRGHGGAAGAGRAGAALPAELAHPAAECVDPAVVFPFPVNKREPAPVPAAPASAPAAGPAVASGAGIAAPAGAPGVAPPRPGGRQTSGGDHKALSTSGEDTLSDSDDEDDEEEDEEEEIDVVTVEKRRSSSNTKAVTTFTITVRPKNAALGPGRAQSSELILKRCLPIHQQHNYAAPSPYVESEDAPPQKKIKSEASPRPLKSVIPPKAKSLSPRNSDSEDSERRRNHNILERQRRNDLRSSFLTLRDHVPELVKNEKAAKVVILKKATEYVHSLQAEEHQLLLEKEKLQARQQQLLKKIEHARTC |
| misc_feature | 1570 | 1656 | 5′→3′ | /gene = MYCN /gene_synonym = bHLHe37; MODED; N-myc; NMYC; ODED /note = propagated from UniProtKB/Swiss-Prot (P04198.2); Region: Interaction with AURKA./evidence=ECO:0000269|PubMed:27837025 |
| misc_feature | 1696 | 1782 | 5′→3′ | /gene = MYCN /gene_synonym = bHLHe37; MODED; N-myc; NMYC; ODED /note = propagated from UniProtKB/Swiss-Prot (P04198.2); Region: Interaction with AURKA and FBXW7./evidence=ECO:0000269|PubMed:27837025 |
| misc_feature | 2296 | 2298 | 5′→3′ | /gene = MYCN /gene_synonym = bHLHe37; MODED; N-myc; NMYC; ODED /note = Phosphoserine, by CK2./evidence=ECO:0000269|PubMed:1425701; propagated from UniProtKB/Swiss-Prot (P04198.2); phosphorylation site |
| misc_feature | 2302 | 2304 | 5′→3′ | /gene = MYCN /gene_synonym = bHLHe37; MODED; N-myc; NMYC; ODED /note = Phosphoserine, by CK2./evidence=ECO:0000269|PubMed:1425701; propagated from UniProtKB/Swiss-Prot (P04198.2); phosphorylation site |
| misc_feature | 5450 | 5515 | 5′→3′ | /gene = MYCN /gene_synonym = bHLHe37; MODED; N-myc; NMYC; ODED /note = propagated from UniProtKB/Swiss-Prot (P04198.2); Region: Leucine-zipper |