FIGURE 2.

CARE stepwise algorithms. a) Treatment algorithm followed by participants in the control group. Daily doses are aged-adjusted; participants aged 5 to 11 years will take 100  µg of fluticasone daily (one puff, twice daily), whereas participants aged ≥12 years will take 200  µg (two puffs, twice daily). Fluticasone will be administered alone (Step 1) or in combination with salmeterol (Step 3). b) Paediatric-dose-adjusted Anti-Inflammatory Reliever (AIR) algorithm followed by participants in the intervention group. Participants will take 100  µg of budesonide daily (one puff, twice daily) at Step 2, and 200  µg of budesonide daily (two puffs, twice daily) at Step 3. ICS: inhaled corticosteroid; LABA: long-acting β₂-agonist.