Table 2.
List of Mtb-encoded proteins that have putative functions in sRNA processing.
| Gene ID | Name | Species | Putative Function |
|---|---|---|---|
| MTB000026 | RnpB | M. bovis, Mtb, M. haemophilum | RNA component of RNase P: RNase P catalyzes the removal of the 5′-leader sequence from pre-tRNA to produce the mature 5′ terminus. |
| rv1340 | RphA | M. marinum, M. leprae, M. bovis, Mtb | Probable ribonuclease RphA (RNase PH). |
| rv2092c | HelY | M. marinum, M. leprae, M. bovis, Mtb, M. abscessus | DNA helicase activity. |
| rv2179c | Rnt | Mtb, M. smegmatis, M. leprae, M. marinum | Conserved hypothetical protein. |
| rv2228c | Rv2228c | N/A | Multifunctional protein. Has RNASE H, alpha-ribazole phosphatase, and acid phosphatase activities. |
| rv2407 | Rnz | Mtb, M. smegmatis, M. leprae, M. marinum, M. bovis | Endonucleolytic cleavage of RNA, removing extra 3′ nucleotides from tRNA precursor, generating 3′ termini of tRNAs. |
| rv2444c | Rne | M. bovis, Mtb, M. leprae, M. marinum, M. smegmatis | Putative RNase E. Plays a central role in the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs. |
| rv2511 | Orn | Mtb, M. smegmatis, M. leprae, M. marinum, M. bovis | Involved in RNA degradation: 3′-to-5′ exoribonuclease specific for small oligoribonucleotides. |
| rv2681 | Rnd | Mtb, M. smegmatis, M. leprae, M. marinum, M. bovis | Conserved hypothetical protein. |
| rv2752c | Rnj | M. bovis, Mtb, M. leprae, M. marinum, M. smegmatis | Conserved hypothetical protein. |
| rv2783c | GpsI (Pnp) | M. marinum, M. leprae, M. bovis, Mtb, M. smegmatis, M. abscessus | Involved in mRNA degradation. Hydrolyses single-stranded polyribonucleotides processively in the 3′ to 5′ direction. |
| rv2902c | RnhB | M. marinum, M. leprae, M.bovis, Mtb, M. abscessus | Probable ribonuclease HII protein RnhB. |
| rv2907c | RimM | M. marinum, M. leprae, M. bovis, Mtb, M. smegmatis, M. abscessus | Essential for efficient processing of 16S rRNA. Probably part of the 30S subunit prior to or during the final step in the processing of 16S free 30S ribosomal subunits. It could be some accessory protein needed for efficient assembly of the 30S subunit. |
| rv2925c | Rnc | M. marinum, M. leprae, M. bovis, Mtb, M. smegmatis, M. abscessus | Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs. |
| rv3853 | RraA | M. leprae, M. bovis, Mtb | Regulator of RNase E activity a RraA. |
| rv3923c | RnpA | M. marinum, M. leprae, M. bovis, Mtb, M. smegmatis, M. abscessus | Ribonuclease P protein component RnpA. |