Table 3.
Factors associated with variation over time of potentially inappropriate medication prescribing (PIP).
| Parameters | Adjusted * Odds Ratio [95CI] | p-Value |
|---|---|---|
| Gender | ||
| Female | Ref. | 0.601 |
| Male | 0.82 [0.38; 1.74] | |
| Age (Years) | ||
| Age ≤ 74 years | Ref. | 0.003 |
| 75 years ≤ Age ≤ 79 years | 2.75 [1.24; 6.09] | |
| Age ≥ 80 years | 5.36 [1.86; 15.44] | |
| Education | ||
| No diploma or primary school certificate | Ref. | 0.590 |
| Secondary education | 1.45 [0.61; 3.47] | |
| High school diploma | 0.87 [0.30; 2.51] | |
| University level | 1.57 [0.64; 3.86] | |
| Intervention Group | ||
| Placebo | Ref. | 0.308 |
| Multidomain plus polyunsaturated fatty acids | 1.25 [0.47; 3.34] | |
| Polyunsaturated fatty acids | 2.48 [0.92; 6.66] | |
| Multidomain plus placebo | 1.20 [0.46; 3.12] | |
| Number of Drugs Prescribed | ||
| Number of drugs prescribed ≤ 4 | Ref. | <0.001 |
| 5 ≤ Number of drugs prescribed ≤ 9 (polypharmacy) | 26.64 [12.29; 57.73] | |
| Number of drugs prescribed ≥ 10 (hyperpolypharmacy) | 662.16 [76.85; 5705.28] | |
| Charlson Comorbidity Index (Baseline) | ||
| 0 point | Ref. | <0.001 |
| 1 point | 10.89 [3.17; 37.35] | |
| ≥2 points | 21.93 [1.48; 324.44] | |
| Frailty | ||
| Robust patients | Ref. | 0.151 |
| Prefrail patients | 1.33 [0.96; 1.84] | |
| Frail patients | 1.95 [0.69; 5.52] |
Legend: PIP = potentially inappropriate medication prescribing; 95CI = 95% confidence interval, * also adjusted on follow-up time (categorical variable: each 6-month follow-up visit).