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. 2021 Nov 4;6(4):93. doi: 10.3390/jfmk6040093

Table 4.

Plasma lactate (mmol/L) at rest with and without L-carnitine supplementation.

Authors N 1 N 2 Carnitine Dosage Mean 1 SD 1 Mean 2 SD 2 SMD SE 95% CI t p Weight (%) Test for Heterogeneity
Fixed Random
Colombani 1996 7 7 4 g/d. 1 d 1.3 0.1 1.4 0.1 −0.936 0.531 −2.092 to 0.220 7.93 7.93 Q 8.0319
Chun 2011 6 6 2 g/d. 4 w 1.88 0.46 1.78 0.28 0.242 0.535 −0.950 to 1.434 7.80 7.80 DF 10
Chun 2011 6 6 3 g/d. 4 w 1.41 0.80 1.04 0.49 0.515 0.543 −0.695 to 1.725 7.57 7.57 Significance level p = 0.6257
Chun 2011 6 6 4 g/d. 4 w 1.10 0.23 1.29 0.36 −0.580 0.546 −1.796 to 0.636 7.49 7.49 I2 (inconsistency) 0.00%
Chun 2011 6 6 5 g/d. 4 w 1.38 0.57 1.50 0.79 −0.161 0.534 −1.350 to 1.029 7.83 7.83 95% CI for I2 0.00 to 50.67
Chun 2011 6 6 6 g/d. 4 w 1.38 0.47 1.31 0.25 0.172 0.534 −1.018 to 1.361 7.83 7.83
Greig 1987 9 9 2 g/d. 2 w 1.04 0.66 1.14 0.28 −0.188 0.450 −1.142 to 0.766 11.02 11.02
Greig 1987 10 10 2 g/d. 4 w 0.8 0.3 0.9 0.3 −0.319 0.431 −1.225 to 0.587 12.00 12.00
Oyono-Enguelle 1988 10 10 2 g/d. 4 w 0.93 0.35 0.86 0.34 0.194 0.429 −0.708 to 1.096 12.11 12.11
Watcher 2002 8 8 4 g/d. 12 w 0.9 0.1 0.8 0.2 0.598 0.484 −0.441 to 1.637 9.52 9.52
Wyss 1990 7 7 3 g/d. 1 w 1.5 0.7 1.4 0.7 0.134 0.501 −0.958 to 1.225 8.90 8.90
Total (fixed effects) 81 81 −0.0257 0.149 −0.321 to 0.269 −0.172 0.864 100.00 100.00
Total (random effects) 81 81 −0.0257 0.149 −0.321 to 0.269 −0.172 0.864 100.00 100.00
Chun 2011 6 6 2 g/d. 4 w 1.88 0.46 1.78 0.28 0.242 0.535 −0.950 to 1.434 24.44 24.44 Q 0.9555
Greig 1987 10 10 2 g/d. 4 w 0.8 0.3 0.9 0.3 −0.319 0.431 −1.225 to 0.587 37.62 37.62 DF 2
Oyono-Enguelle 1988 10 10 2 g/d. 4 w 0.93 0.35 0.86 0.34 0.194 0.429 −0.708 to 1.096 37.94 37.94 Significance level p = 0.6202
Total (fixed effects) 26 26 0.0129 0.264 −0.518 to 0.544 0.0486 0.961 100.00 100.00 I2 0.00%
Total (random effects) 26 26 0.0129 0.264 −0.518 to 0.544 0.0486 0.961 100.00 100.00 95% CI for I2 0.00 to 92.98

Mm: Millimoles, l: liter, d: day; L-carn: L-carnitine, N: number of subjects, 1: subjects that did not use supplementation, 2: subjects used L-carnitine, g: grams, w: weeks, SMD: standard mean differences, SE: standard error, CI: confidential intervals, SD: standard deviation, I2: inconsistency.