. Author manuscript; available in PMC: 2021 Nov 29.

Published in final edited form as: J Med Chem. 2020 Oct 7;63(20):12060–12072. doi: 10.1021/acs.jmedchem.0c01394

Table 3.

The in vitro stability of compounds 13-15

Compound	The plasma stability	The microsome stability		The solution stability
	The intact ± SEM at 120 min (%)	t_1/2 (min)	CL_int (mL/min/mg protein)	The intact ± SEM at 120 min (%)
	The intact ± SEM at 120 min (%)	t_1/2 (min)	CL_int (mL/min/mg protein)	pH = 5.0	pH = 7.4	pH = 9.4
13	96.6 ± 2.1	74.5	17.9	95.3 ± 0.3	94.5 ± 0.4	96.1 ± 0.7
14	89.2 ± 0.6	73.7	18.1	---	---	---
Diltiazem	43.2 ± 0.8	---	---	---	---	---
ML128	---	4.2	317.1	---	---	---