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Circulating concentration of A, alanine transaminase (ALT; IU/L) and B, K18 (U/L) for sequential samples in patients within the SAEFRIF trial. Black dots show patients with normal ALT throughout treatment, red points show patients whose ALT rises >50 IU/L during treatment, blue points show patients whose ALT falls from >50 IU/L upon starting treatment. Dotted line on (A) ALT = 50 IU/L
