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. 2020 Mar 10;84(4):1844–1856. doi: 10.1002/mrm.28241

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© 2020 The Authors. Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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A, Pulse sequence used to measure the ¹H−¹⁵N cross relaxation rate in a 500 mM [¹⁵N₂]urea sample. B, Plot of ¹⁵N signal versus mixing time. Signal intensity was fitted to an analytical solution of the Solomon equations (Equations 5 and 6). NOE, nuclear Overhauser enhancement

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