Table 2. PenA alleles among PenR and PenI IMD isolates in England, Wales and Northern Ireland from 2010/11 to 2018/19.
| penA allele | Total number of isolates | Number of PenS isolates | Number of PenI isolates | Number of PenR isolates | MIC value or range (mg/L) | MIC50 | MIC90 | Number of penicillin resistance associated AASs |
|---|---|---|---|---|---|---|---|---|
| 1 | 1549 | 1327 | 222 | 0 | 0.004–0.25 | 0.047 | 0.094 | 0 |
| 2 | 84 | 61 | 23 | 0 | 0.016–0.25 | 0.064 | 0.125 | 0 |
| 3 | 364 | 259 | 105 | 0 | 0.047–0.25 | 0.064 | 0.094 | 0 |
| 4 | 13 | 11 | 2 | 0 | 0.016–0.094 | 0.047 | 0.094 | 0 |
| 5 | 73 | 66 | 7 | 0 | 0.012–0.19 | 0.047 | 0.064 | 0 |
| 7 | 257 | 7 | 243 | 7 | 0.064–0.38 | 0.19 | 0.25 | 5 |
| 9 | 86 | 1 | 59 | 26 | 0.047–0.75 | 0.25 | 0.38 | 5 |
| 10 | 5 | 0 | 2 | 3 | 0.25–0.38 | 5 | ||
| 11 | 1 | 0 | 0 | 1 | 0.5 | 5 | ||
| 12 | 16 | 0 | 14 | 2 | 0.125–0.5 | 0.19 | 0.38 | 5 |
| 13 | 7 | 0 | 5 | 2 | 0.125–0.38 | 5 | ||
| 14 | 308 | 11 | 285 | 12 | 0.047–0.5 | 0.19 | 0.25 | 5 |
| 16 | 9 | 8 | 1 | 0 | 0.023–0.094 | 0 | ||
| 19 | 22 | 1 | 18 | 3 | 0.047–0.38 | 0.19 | 0.38 | 5 |
| 20 | 6 | 0 | 5 | 1 | 0.125–0.5 | 5 | ||
| 21 | 3 | 0 | 1 | 2 | 0.19–0.38 | 5 | ||
| 22 | 571 | 473 | 98 | 0 | 0.012–0.19 | 0.064 | 0.094 | 0 |
| 25 | 3 | 0 | 2 | 1 | 0.125–0.38 | 5 | ||
| 27 | 196 | 188 | 8 | 0 | 0.008–0.125 | 0.047 | 0.064 | 0 |
| 33 | 43 | 0 | 27 | 16 | 0.094–0.75 | 0.25 | 0.5 | 5 |
| 34 | 122 | 105 | 17 | 0 | 0.012–0.19 | 0.047 | 0.094 | 0 |
| 42 | 11 | 0 | 10 | 1 | 0.125–0.38 | 0.19 | 0.25 | 5 |
| 52 | 60 | 1 | 57 | 2 | 0.064–0.38 | 0.19 | 0.25 | 5 |
| 54 | 1 | 0 | 0 | 1 | 0.38 | 5 | ||
| 62 | 5 | 3 | 2 | 0 | 0.032–0.094 | 0 | ||
| 66 | 5 | 0 | 5 | 0 | 0.094–0.25 | 5 | ||
| 83 | 4 | 2 | 2 | 0 | 0.047–0.125 | 0 | ||
| 90 | 5 | 0 | 5 | 0 | 0.125–0.19 | 5 | ||
| 91 | 4 | 0 | 4 | 0 | 0.125–0.19 | 5 | ||
| 110 | 2 | 0 | 1 | 1 | 0.125–0.38 | 5 | ||
| 119 | 4 | 1 | 3 | 0 | 0.032–0.125 | 0 | ||
| 157 | 15 | 14 | 1 | 0 | 0.032–0.094 | 0.047 | 0.064 | 0 |
| 171 | 1 | 0 | 0 | 1 | 0.38 | 0 | ||
| 179 | 1 | 0 | 0 | 1 | 0.38 | 5 | ||
| 209 | 1 | 0 | 0 | 1 | 0.5 | 3 | ||
| 238 | 5 | 0 | 5 | 0 | 0.094–0.19 | 5 | ||
| 248 | 46 | 1 | 35 | 10 | 0.047–0.38 | 0.25 | 0.38 | 5 |
| 295 | 6 | 0 | 3 | 3 | 0.25–0.5 | 5 | ||
| 327 | 5 | 1 | 3 | 1 | 0.047–0.38 | 4 | ||
| 331 | 1 | 0 | 0 | 1 | 0.5 | 5 | ||
| 342 | 4 | 2 | 2 | 0 | 0.047–0.094 | 0 | ||
| 348 | 16 | 2 | 11 | 3 | 0.047–0.38 | 0.125 | 0.38 | 5 |
| 371 | 5 | 0 | 4 | 1 | 0.125–0.38 | 5 | ||
| 386 | 10 | 1 | 9 | 0 | 0.047–0.125 | 0.125 | 0.125 | 5 |
| 414 | 8 | 0 | 7 | 1 | 0.125–0.38 | 5 | ||
| 419 | 1 | 0 | 0 | 1 | 0.5 | 5 | ||
| 420 | 8 | 0 | 8 | 0 | 0.125–0.25 | 5 | ||
| 435 | 1 | 0 | 0 | 1 | 0.38 | 5 | ||
| 540 | 6 | 0 | 1 | 5 | 0.25–0.38 | 5 | ||
| 593 | 1 | 0 | 0 | 1 | 0.38 | 5 | ||
| 921 | 1 | 0 | 0 | 1 | 0.38 | 5 |
Alleles among n = 3,981 IMD isolates. Alleles among PenI IMD isolates represented by 4+ isolates only. PenS = Penicillin-susceptible, standard exposure; PenI = Penicillin-susceptible, increased exposure; PenR = Penicillin-resistant according to EUCAST guidelines. MIC50 and MIC90 calculated for ≥10 isolates. AASs = amino acid substitutions.