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. 2021 Nov 9;17(11):e1009433. doi: 10.1371/journal.ppat.1009433

Fig 5. High extrinsic incubation temperature increases variant fixation in Aedes aegypti.

Fig 5

Indicated mutations were engineered into a ZIKV-PR-IC and mixed with a ZIKV-REF virus. The proportion of each competitor (grey, mean with 95% CI, *p-value < 0.05 compared with ZIKV-PR-IC, Kruskal-Wallis and Dunn’s) and rate of fixation (*p-value < 0.05 compared with ZIKV-PR-IC, Two-tailed Fisher’s exact test) was determined from mosquito bodies at 14-dpi for Ae. aegypti mosquitoes held at constant EIT’s 25°C (A) & 35°C (B). Fixation indicates that 100% of the sequenced nucleotides were from the competitor virus. Initial viral inoculum (ratio of competitor virus to reference) is shown in red symbols.