Table 1.

Systemic Inflammatory Index Pre and Post Surgery According to Minimal Residual Disease Subtype

	Group I MRD negative N=105	Group II CTC (-) mM (+) N=36	Group III CTC (+) N=40	p=value
SII Median (IQR)
Pre-surgery	752 (575-1081)	561 (500-897)	1174 (647-1274)	NS
Post-surgery	617 (380-816)	687 (450-919)	947 (647-12363)	I vs III p=0.04
	p=0.56	p=0.34	p=0.66	II vs III p=0.03
				I vs II p=0.73
Nº CTCs post-surgery
0			617 (380-816)	0 vs 1-2 p=0.049
1-2			739 (634-1081)	0 vs ≥3 p=0.4
≥ 3			1084 8947-2032)	1-2 vs ≥3 p=0.04
SII >700
Pre-surgery	43 (41%)	12 (33%)	26 (70%)	I vs II p=0.54ª
				I vs III p=0.003ª
				II vs III p=0.003ª
Post-surgery	28 (27%)	14 (39%)	26 (65%)	I vs II p=0.39ª
	p=0.04ª	p=0.89ª	p=0.81ª	I vs III p=0.01ª
				II vs III p=0.04ª
SII >900
Pre-surgery	37 (35%	10 (28%)	26 (65%)	I vs II p=0.48ª
				I vs III p=0.003ª
				II vs III p0.003ª
Post-surgery	22 (21%)	12 (33%)	24 (60)	I vs II p=0.20
	p=0.03ª	p=0.79ª	p=0.82ª	I vs III p=0.001ª
				II vs III p=0.03ª

CTC, circulating tumour cell; mM, micro-metastasis; SII, systemic inflammatory index; IQR, inter-quartile range; ª, Pearsons chi squared test; NS, not significant