Table 2.

Meta-Analysis Results of Association between PON1 rs662 Polymorphism and Breast Cancer Risk

Polymorphism	Genetic Model	Type of Model	Heterogeneity		Odds Ratio				Publication Bias
			I2 (%)	PH	OR	95% CI	Ztest	POR	PBeggs	PEggers
Overall	G vs. A	Random	91.39	≤0.001	0.719	0.648-0.798	-6.234	≤0.001	0.063	0.467
	GG vs. AA	Random	73.8	≤0.001	0.542	0.332-0.885	-2.446	0.014	0.035	0.221
	GA vs. AA	Fixed	14.09	0.32	1.011	0.800-1.278	0.092	0.926	0.901	0.374
	GG+GA vs. AA	Random	90.55	≤0.001	0.534	0.330-0.864	-2.554	0.011	0.107	0.428
	GG vs. GA+AA	Random	62.05	0.01	0.72	0.492-1.053	-1.696	0.09	0.173	0.576
Ethnicity
Caucasian	G vs. A	Random	94.69	≤0.001	0.48	0.220-1.047	-1.846	0.065	1	0.694
	GG vs. AA	Random	82.08	0.001	0.341	0.134-0.866	-2.262	0.024	1	0.479
	GA vs. AA	Random	57.75	0.069	0.894	0.481-1.661	-0.355	0.723	0.734	0.486
	GG+GA vs. AA	Random	93.93	≤0.001	0.317	0.119-0.839	-2.312	0.021	1	0.578
	GG vs. GA+AA	Random	78.94	0.003	0.594	0.278-1.269	-1.345	0.179	0.734	0.872
Asian	G vs. A	Fixed	41.99	0.189	0.951	0.810-1.116	-0.617	0.537	NA	NA
	GG vs. AA	Fixed	0	0.378	0.943	0.663-1.341	-0.326	0.744	NA	NA
	GA vs. AA	Fixed	0	0.952	1.027	0.721-1.462	0.146	0.884	NA	NA
	GG+GA vs. AA	Fixed	50.42	0.159	0.931	0.751-1.153	-0.658	0.511	NA	NA
	GG vs. GA+AA	Fixed	0	0.607	0.959	0.688-1.337	-0.247	0.805	NA	NA
Source of Controls
HB	G vs. A	Fixed	54.8	0.109	0.923	0.789-1.079	-1.01	0.313	0.296	0.332
	GG vs. AA	Fixed	36.58	0.207	0.878	0.625-1.233	-0.75	0.453	0.296	0.105
	GA vs. AA	Fixed	0	0.918	1.05	0.750-1.470	0.284	0.777	0.296	0.163
	GG+GA vs. AA	Fixed	52.79	0.12	0.904	0.732-1.117	-0.933	0.351	0.296	0.429
	GG vs. GA+AA	Fixed	0	0.514	0.907	0.662-1.243	-0.609	0.543	0.296	0.007
PB	G vs. A	Random	93.28	≤0.001	0.563	0.311-1.020	-1.895	0.058	0.462	0.793
	GG vs. AA	Random	77.27	0.001	0.445	0.215-0.920	-2.186	0.029	0.462	0.645
	GA vs. AA	Fixed	49.26	0.096	0.976	0.704-1.353	-0.147	0.883	0.22	0.354
	GG+GA vs. AA	Random	92.42	≤0.001	0.429	0.209-0.878	-2.316	0.021	0.462	0.657
	GG vs. GA+AA	Random	73.1	0.005	658	0.351-1.232	-1.307	0.191	0.806	0.96