Table 3.

Meta-Analysis Results of Association between PON1 rs854560 Polymorphism and Breast Cancer Risk

Polymorphism	Genetic Model	Type of Model	Heterogeneity		Odds Ratio				Publication Bias
			I2 (%)	PH	OR	95% CI	Ztest	POR	PBeggs	PEggers
Overall	A vs. T	Random	92.43	≤0.001	2.107	1.401-3.167	3.582	≤0.001	0.22	0.21
	AA vs. TT	Random	81.73	≤0.001	3.214	1.757-5.879	3.789	≤0.001	0.462	0.27
	AT vs. TT	Random	81.85	≤0.001	0.379	0.208-0.691	-3.17	0.002	1	0.478
	AA+AT vs. TT	Random	81.83	≤0.001	1.868	1.293-2.700	3.326	0.001	0.22	0.12
	AA vs. AT+TT	Random	84.64	≤0.001	3.067	1.687-5.575	3.674	≤0.001	0.462	0.375
Ethnicity
Asian	A vs. T	Random	82.54	0.003	1.785	1.150-2.772	2.581	0.01	0.296	0.248
	AA vs. TT	Fixed	0	0.536	2.387	1.573-3.622	4.09	≤0.001	1	0.152
	AG vs. TT	Random	77.65	0.011	0.792	0.313-2.001	-0.493	0.622	1	0.751
	AA+AT vs. TT	Random	93.29	≤0.001	1.212	0.469-3.132	0.397	0.691	1	0.802
	AA vs. AT+TT	Fixed	0	0.442	2.043	1.383-3.016	3.592	≤0.001	0.296	0.317
Caucasian	A vs. T	Random	93.83	≤0.001	1.56	0.941-2.587	1.725	0.085	NA	NA
	AA vs. TT	Fixed	73.12	0.054	2.086	1.650-2.638	6.143	≤0.001	NA	NA
	AG vs. TT	Random	79.06	0.029	0.559	0.331-0.946	-2.169	0.03	NA	NA
	AA+AT vs. TT	Random	79.34	0.028	1.491	0.987-2.253	1.897	0.058	NA	NA
	AA vs. AT+TT	Fixed	81.38	0.02	1.878	1.134-3.109	2.45	0.014	NA	NA
Source of Controls
HB	A vs. T	Random	82.54	0.003	1.785	1.150-2.772	2.581	0.01	0.296	0.248
	AA vs. TT	Random	90.35	≤0.001	3.48	1.455-8.321	2.804	0.005	1	0.478
	AG vs. TT	Random	90.91	≤0.001	0.316	0.131-0.761	-2.567	0.01	1	0.501
	AA+AT vs. TT	Random	93.29	≤0.001	1.212	0.469-3.132	0.397	0.691	1	0.802
	AA vs. AT+TT	Random	92.04	≤0.001	3.359	1.432-7.879	2.785	0.005	1	0.566
PB	A vs. T	Random	95.14	≤0.001	2.254	1.228-4.140	2.622	0.009	1	0.482
	AA vs. TT	Random	90.35	≤0.001	3.48	1.455-8.321	2.804	0.005	1	0.478
	AG vs. TT	Random	90.91	≤0.001	0.316	0.131-0.761	-2.567	0.01	1	0.501
	AA+AT vs. TT	Random	82.19	0.004	1.84	1.137-2.976	2.483	0.013	0.296	0.413
	AA vs. AT+TT	Fixed	0	0.465	2.038	1.380-3.009	3.58	≤0.001	0.296	0.33