Table 5.

Meta-Analysis Results of Association between LEPR rs1137101 Polymorphism and Breast Cancer Risk

Polymorphism	Genetic Model	Type of Model	Heterogeneity		Odds Ratio				Publication Bias
			I2 (%)	PH	OR	95% CI	Ztest	POR	PBeggs	PEggers
Overall	A vs. G	Random	86.48	≤0.001	0.943	0.780-1.139	-0.614	0.539	0.661	0.781
	AA vs. GG	Random	84.75	≤0.001	0.928	0.631-1.365	-0.379	0.705	0.76	0.867
	AG vs. GG	Random	74.12	≤0.001	0.991	0.763-1.289	-0.064	0.949	0.669	0.717
	AA+AG vs. GG	Random	83.33	≤0.001	0.994	0.742-1.331	-0.041	0.967	0.427	0.761
	AA vs. AG+GG	Random	76.74	≤0.001	0.965	0.767-1.214	-0.302	0.763	0.745	0.867
Ethnicity
Caucasian	A vs. G	Fixed	41.76	0.161	0.977	0.916-1.043	-0.688	0.491	0.734	0.349
	AA vs. GG	Fixed	41.86	0.16	0.96	0.842-1.094	-0.615	0.539	0.734	0.285
	AG vs. GG	Fixed	0	0.92	0.983	0.873-1.107	-0.287	0.774	1	0.202
	AA+AG vs. GG	Fixed	0	0.859	0.996	0.892-1.112	-0.071	0.944	1	0.273
	AA vs. AG+GG	Fixed	55.12	0.083	0.976	0.883-1.079	-0.468	0.639	0.734	0.431
Asian	A vs. G	Random	89.54	≤0.001	0.711	0.419-1.207	-1.264	0.206	1	0.907
	AA vs. GG	Random	87.83	≤0.001	0.442	0.124-1.570	-1.262	0.207	1	0.762
	AG vs. GG	Random	86.29	≤0.001	0.749	0.273-2.054	-0.562	0.574	0.452	0.394
	AA+AG vs. GG	Random	90.55	≤0.001	0.595	0.201-1.758	-0.939	0.347	0.452	0.397
	AA vs. AG+GG	Random	72.07	0.001	0.664	0.413-1.066	-1.697	0.09	0.763	0.888
African	A vs. G	Fixed	3.035	0.357	1.386	1.161-1.654	3.612	≤0.001	1	0.813
	AA vs. GG	Fixed	2.894	0.358	1.931	1.339-2.786	3.52	≤0.001	1	0.598
	AG vs. GG	Fixed	61.34	0.075	1.337	1.010-1.772	2.026	0.043	0.296	0.11
	AA+AG vs. GG	Fixed	0	0.423	1.647	1.268-2.137	3.747	≤0.001	1	0.916
	AA vs. AG+GG	Fixed	63.26	0.066	1.845	0.997-3.415	1.949	0.051	0.296	0.199
Source of Controls
HB	A vs. G	Random	93.07	≤0.001	0.931	0.504-1.721	-0.227	0.82	0.806	0.83
	AA vs. GG	Random	93.33	≤0.001	0.964	0.209-4.445	-0.047	0.963	1	0.815
	AG vs. GG	Random	90.34	≤0.001	0.866	0.285-2.629	-0.254	0.799	0.734	0.597
	AA+AG vs. GG	Random	93.72	≤0.001	0.836	0.230-3.041	-0.272	0.786	0.734	0.651
	AA vs. AG+GG	Random	81.48	≤0.001	0.963	0.567-1.635	-0.141	0.888	0.806	0.43
PB	A vs. G	Random	86.15	≤0.001	0.816	0.666-0.999	-1.967	0.049	0.465	0.244
	AA vs. GG	Random	72.44	0.001	0.893	0.758-1.051	-1.361	0.173	0.367	0.271
	AG vs. GG	Fixed	8.403	0.364	0.979	0.871-1.100	-0.359	0.719	0.763	0.753
	AA+AG vs. GG	Fixed	40.64	0.12	0.974	0.875-1.086	-0.471	0.638	0.133	0.23
	AA vs. AG+GG	Random	67.54	0.005	0.882	0.699-1.112	-1.063	0.288	0.367	0.249