JPRN‐UMIN000012635.

Methods	Study design: RCT Setting: Japan
Participants	30 participants aged between 16 and 70 years old
Interventions	IG: oral administration of Daikenchuto 15 g/day for 24 weeks in addition to ordinary treatment for Crohn's disease CG: ordinary treatment for Crohn's disease
Outcomes	Date of first enrolment: 25 December 2013 Estimated completion date: NS Outcomes: Primary Abdominal pain (the item 'abdominal pain in the past week' in CDAI) Abdominal bloating (questions 17 and 20 in Japanese version of IBDQ) Secondary CDAI Japanese version of IBDQ Serum concentrations and blood mRNA levels of following substances: adrenomedullin, calcitonin gene‐related peptide, receptors for adrenomedullin or calcitonin gene‐related peptide and cytokines Protein and mRNA levels of following substances in peripheral mononuclear cells: adrenomedullin, calcitonin gene‐related peptide, cytokines and their receptors Discontinuance rate of study
Notes	Funding: Kurume University, Tsumura & Co. Contact: nina@med.kurume‐u.ac.jp We received no response from the author and were therefore unable to determine whether this study meets our inclusion criteria.