Table 1.
Baseline clinical characteristics of patients with HNSCC in TCGA and GSE65858 cohorts.
| Clinical characteristics | TCGA | GSE65858 | ||
|---|---|---|---|---|
| Total (n = 494) | % | Total (n = 266) | % | |
| Age | ||||
| <65 | 306 | 61.9 | 180 | 67.7 |
| ≥65 | 188 | 38.1 | 86 | 32.3 |
| Gender | ||||
| Female | 132 | 26.7 | 45 | 16.9 |
| Male | 362 | 73.3 | 221 | 83.1 |
| Grade | ||||
| G1 | 61 | 12.3 | — | — |
| G2 | 294 | 59.5 | — | — |
| G3 | 118 | 23.9 | — | — |
| G4 | 2 | 0.4 | — | — |
| GX | 16 | 3.2 | — | — |
| Unknown | 3 | 0.6 | — | — |
| Stage | ||||
| I | 24 | 4.9 | 18 | 6.8 |
| II | 72 | 14.6 | 37 | 13.9 |
| III | 78 | 15.8 | 36 | 13.5 |
| IV | 256 | 51.8 | 175 | 65.8 |
| Unknown | 64 | 13.0 | — | — |
| T-stage | ||||
| T0 | 1 | 0.2 | — | — |
| T1 | 44 | 8.9 | 35 | 13.2 |
| T2 | 131 | 26.5 | 80 | 30.1 |
| T3 | 95 | 19.2 | 56 | 21.1 |
| T4 | 169 | 34.2 | 95 | 35.7 |
| TX | 32 | 6.5 | — | — |
| Unknown | 22 | 4.5 | — | — |
| N-stage | ||||
| N0 | 168 | 34.0 | 93 | 35.0 |
| N1 | 65 | 13.2 | 31 | 11.7 |
| N2 | 162 | 32.8 | 130 | 48.9 |
| N3 | 7 | 1.4 | 12 | 4.5 |
| NX | 68 | 13.8 | — | — |
| Unknown | 24 | 4.9 | — | — |
| M-stage | ||||
| M0 | 181 | 36.6 | 259 | 97.4 |
| M1 | 1 | 0.2 | 7 | 2.6 |
| MX | 61 | 12.3 | — | — |
| Unknown | 251 | 50.8 | — | — |
| HPV status | ||||
| HPV16 | — | — | 60 | 22.6 |
| Other HPV | — | — | 13 | 4.9 |
| Negative | — | — | 192 | 72.2 |
| Unknown | — | — | 1 | 0.4 |
| HPV16 | ||||
| DNA(+) RNA(+) | — | — | 35 | 13.2 |
| DNA(+) RNA(-) | — | — | 19 | 7.1 |
| DNA(-) | — | — | 192 | 72.2 |
| Unknown | — | — | 20 | 7.5 |
| P16 | ||||
| Negative | 72 | 14.6 | — | — |
| Positive | 30 | 6.1 | — | — |
| Unknown | 392 | 79.4 | — | — |
| HPV-ISH result | ||||
| Negative | 64 | 13.0 | — | — |
| Positive | 19 | 3.8 | — | — |
| Unknown | 411 | 83.2 | — | — |
HNSCC: head and neck squamous cell carcinoma; HPV: human papillomavirus; TCGA: The Cancer Genome Atlas; ISH: in situ hybridization.