Table 1.
Demographics and baseline characteristics
| Immunogenicity/reactogenicity cohort (N=400) |
Safety cohort (N=1200) |
All SII-ChAdOx1 nCoV-19 (N=1200) | |||
|---|---|---|---|---|---|
| Parameter | SII-ChAdOx1 nCoV-19 (N=300) | AZD1222 (N=100) | SII-ChAdOx1 nCoV-19 (N=900) | Placebo (N=300) | |
| Age, years | 46·4 (15·13) | 46·8 (16·29) | 40·6 (12·22) | 40·2 (13·26) | 42·1 (13·24) |
| [range] | [19–83] | [20–80] | [18–84] | [18–77] | [18–84] |
| Age group | |||||
| 18–59 years | 225 (75·0) | 74 (74·0) | 823 (91·4) | 271 (90·3) | 1048 (87·3) |
| ≥60 years | 75 (25·0) | 26 (26·0) | 77 (8·6) | 29 (9·7) | 152 (12·7) |
| Sex | |||||
| Male | 228 (76·0) | 80 (80·0) | 697 (77·4) | 218 (72·7) | 925 (77·1) |
| Female | 72 (24·0) | 20 (20·0) | 203 (22·6) | 82 (27·3) | 275 (22·9) |
| Height, cm | 167·6 (9·20) | 167·0 (8·47) | 167·1 (9·03) | 165·7 (8·74) | 167·2 (9·07) |
| Weight, kg | 68·58 (12·289) | 69·98 (14·154) | 71·81 (13·565) | 69·66 (13·608) | 71·00 (13·327) |
| Body Mass Index (kg/m2) | 24·40 (3·871) | 25·05 (4·433) | 25·68 (4·197) | 25·29 (4·185) | 25·36 (4·154) |
| Baseline SARS-CoV-2 serostatus | |||||
| Seropositive | 9 (3·0) | 2 (2·0) | 17 (1·9) | 4 (1·3) | 26 (2·2) |
| Seronegative | 291 (97·0) | 98 (98·0) | 883 (98·1) | 296 (98·7) | 1174 (97·8) |
| Comorbidities* | 53 (17·7) | 26 (26·0) | 231 (25·7) | 68 (22·7) | 284 (23·7) |
Data are n (%) or mean (SD), except where stated.
A participant was considered as having a comorbidity if they either had a body mass index ≥30 or had one of the following reported terms for medical history: allergic bronchitis, asthma, atrial fibrillation, bronchiectasis, cardiac operation, chronic heart failure, chronic obstructive pulmonary disease, coronary angioplasty, coronary artery bypass, coronary artery disease, diabetes mellitus, dyslipidaemia, essential hypertension, gout, hepatic cirrhosis, hypercholesterolaemia, hyperglycaemia, hyperlipidaemia, hypertension, hyperthyroidism, hypocholesterolaemia, hypothyroidism, ischaemic heart disease, metabolic surgery, myocardial infarction, myocardial ischaemia, nephrectomy, peripheral artery stent insertion, peripheral vascular disease, prostate cancer, renal artery stenosis, seizure, spleen operation, tongue neoplasm malignant stage unspecified, type 1 diabetes mellitus, type 2 diabetes mellitus, valvular heart disease. SD=standard deviation.