Supplementary Table 2. Patient baseline characteristics and lipid profiles, and LLT post ACS and change in LDL-C: subgroup analysis by quartile of percent LDL-C change from the first measurement after hospitalization to Visit 1 § .
| All patients ( n = 1,585) |
Q1 ( n = 391) |
Q2 ( n = 388) |
Q3 ( n = 404) |
Q4 ( n = 402) |
P -value | |
|---|---|---|---|---|---|---|
| Age, years, mean (SD) | 66.2 (12.2) | 65.2 (12.1) | 65.2 (12.5) | 66.4 (12.0) | 67.9 (11.8) | 0.003 |
| Male, n (%) | 1,268 (80.0) | 310 (78.3) | 317 (80.3) | 324 (81.6) | 317 (79.8) | 0.706 |
| BMI, kg/m 2 , mean (SD) | 24.2 (3.5) | 24.4 (3.4) | 24.2 (3.4) | 24.4 (3.5) | 23.7 (3.8) | 0.007 |
| ACS type, n (%) | ＜0.001 | |||||
| STEMI | 992 (62.6) | 279 (70.5) | 252 (63.8) | 240 (60.5) | 221 (55.7) | |
| UA | 347 (21.9) | 53 (13.4) | 79 (20.0) | 111 (28.0) | 104 (26.2) | |
| Non-STEMI | 246 (15.5) | 64 (16.2) | 64 (16.2) | 46 (11.6) | 72 (18.1) | |
| eGFR ＜15 mL/min/1.73 m 2 , n (%) | 27 (1.7) | 4 (1.0) | 4 (1.0) | 9 (2.3) | 10 (2.5) | 0.835 |
| LDL-C, mean (SD), mg/dL, first measurement # | 122.6 (39.5) | 144.0 (37.2) | 131.6 (36.7) | 114.2 (33.0) | 100.8 (36.4) | ＜0.001 |
| Baseline lipid profile (Visit 1), mg/dL | ||||||
| LDL-C, mean (SD), calculated | 98.9 (31.4) | 82.5 (22.2) | 98.7 (27.8) | 103.3 (29.8) | 111.0 (36.8) | ＜0.001 |
| HDL-C, mean (SD) | 40.8 (11.6) | 38.5 (11.4) | 40.4 (11.0) | 41.2 (11.1) | 43.0 (12.4) | ＜0.001 |
| Triglycerides, median (min, max) | 109 (22, 361) | 109 (33, 340) | 108 (31, 361) | 114 (38, 358) | 104 (22, 340) | 0.014 |
| Total cholesterol, mean (SD) | 163.6 (37.0) | 144.9 (27.9) | 163.1 (33.1) | 169.6 (36.0) | 176.7 (42.0) | ＜0.001 |
| History of CV risk factors/comorbidities, n (%) | ||||||
| Dyslipidemia | 1,240 (78.2) | 309 (78.0) | 302 (77.0) | 319 (80.4) | 308 (77.6) | 0.675 |
| Hypertension | 1,154 (72.8) | 281 (71.0) | 279 (70.6) | 305 (76.8) | 289 (72.8) | 0.182 |
| Diabetes mellitus | 552 (34.8) | 141 (35.6) | 131 (33.2) | 139 (35.0) | 141 (35.5) | 0.879 |
| Smoking | 0.002 | |||||
| Current smoker | 610 (38.5) | 163 (41.2) | 156 (39.5) | 155 (39.0) | 136 (34.3) | |
| Previous smoker | 452 (28.5) | 116 (29.3) | 122 (30.9) | 110 (27.7) | 104 (26.2) | |
| None | 523 (33.0) | 117 (29.5) | 117 (29.6) | 132 (33.2) | 157 (39.5) | |
| Coronary artery disease | 281 (17.7) | 41 (10.4) | 49 (12.4) | 81 (20.4) | 110 (27.7) | |
| Cerebrovascular accident | 126 (7.9) | 29 (7.3) | 29 (7.3) | 36 (9.1) | 32 (8.1) | |
| Dialysis | 24 (1.5) | 2 (0.5) | 3 (0.8) | 9 (2.3) | 10 (2.5) | |
| Peripheral artery disease | 29 (1.8) | 7 (1.8) | 7 (1.8) | 6 (1.5) | 9 (2.3) | |
| LLT at Visit 1 ( n / N ), n (%) | ||||||
| Statin | 385/396 (97.2) | 373/395 (94.4) | 373/397 (94.0) | 356/397 (89.7) | ||
| Intensive statin | 43/396 (10.9) | 27/395 (6.8) | 24/397 (6.0) | 27/397 (6.8) | ||
| Ezetimibe | 18/396 (4.5) | 11/395 (2.8) | 17/397 (4.3) | 16/397 (4.0) | ||
| Change in LDL-C from first measurement after hospitalization to Visit 1 | ||||||
| Number | 396 | 395 | 397 | 397 | ||
| mg/dL, mean (SD) | −42.3 (7.98) | −25.0 (4.27) | −9.3 (4.44) | 13.8 (31.57) |
§ Evaluated patients with available and changed LDL-C measurement at Visit 1.
# At first measurement after hospitalization.
Visit 1 was within 14 days of hospitalization for ACS.
ACS, acute coronary syndrome; BMI, body mass index; CV, cardiovascular; eGFR, estimated glomerular filtration rate; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; LLT, lipid-lowering therapy; SD, standard deviation; STEMI, ST-segment- elevation myocardial infarction; UA, unstable angina.