Supplementary Table 4. Patient baseline characteristics and lipid profiles, and LLT post ACS and change in LDL-C: subgroup analysis by quartile of percent LDL-C change from the first measurement after hospitalization to Visit 3 § .
| All patients ( n = 1,411) |
Q1 ( n = 335) |
Q2 ( n = 335) |
Q3 ( n = 335) |
Q4 ( n = 336) |
P -value | |
|---|---|---|---|---|---|---|
| Age, years, mean (SD) | 66.0 (12.1) | 62.3 (12.6) | 65.3 (12.0) | 67.2 (11.6) | 69.2 (11.4) | ＜0.001 |
| Male, n (%) | 1,135 (80.4) | 281 (83.9) | 279 (83.3) | 262 (78.2) | 253 (75.3) | 0.013 |
| BMI, kg/m 2 , mean (SD) | 24.2 (3.5) | 24.9 (3.4) | 24.5 (3.4) | 23.7 (3.5) | 23.6 (3.3) | ＜0.001 |
| ACS type, n (%) | 0.007 | |||||
| STEMI | 871 (61.7) | 231 (69.0) | 214 (63.9) | 203 (60.6) | 187 (55.7) | |
| UA | 314 (22.3) | 62 (18.5) | 64 (19.1) | 73 (21.8) | 90 (26.8) | |
| Non-STEMI | 226 (16.0) | 42 (12.5) | 57 (17.0) | 59 (17.6) | 59 (17.6) | |
| eGFR ＜15 mL/min/1,73 m 2 , n (%) | 23 (1.7) | 0 (0.3) | 2 (0.6) | 5 (1.5) | 15 (4.6) | 0.007 |
| LDL-C, mean (SD), mg/dL, first measurement # | 121.5 (39.0) | 153.1 (38.6) | 129.7 (32.7) | 111.5 (27.7) | 91.9 (26.8) | ＜0.001 |
| Baseline lipid profile (Visit 1), mg/dL | ||||||
| LDL-C, mean (SD), calculated | 98.8 (30.9) | 107.7 (36.8) | 100.7 (30.8) | 95.4 (25.4) | 89.6 (26.5) | ＜0.001 |
| HDL-C, mean (SD) | 41.2 (11.6) | 39.6 (10.9) | 40.6 (11.2) | 42.5 (12.6) | 42.0 (11.7) | 0.004 |
| Triglycerides, median (min, max) | 108 (25, 552) | 117 (31, 408) | 106 (35, 552) | 107 (25, 436) | 101 (36, 441) | ＜0.001 |
| Total cholesterol, mean (SD) | 164.0 (37.2) | 173.3 (41.8) | 165.7 (39.1) | 161.4 (32.0) | 153.7 (31.7) | ＜0.001 |
| History of CV risk factors/comorbidities, n (%) | ||||||
| Dyslipidemia | 1,109 (78.6) | 275 (82.1) | 262 (78.2) | 249 (74.3) | 269 (80.1) | 0.089 |
| Hypertension | 1,040 (73.7) | 232 (69.3) | 238 (71.0) | 257 (76.7) | 260 (77.4) | 0.036 |
| Diabetes mellitus | 465 (33.0) | 104 (31.0) | 104 (31.0) | 100 (29.9) | 135 (40.2) | 0.015 |
| Smoking | 0.006 | |||||
| Current smoker | 525 (37.2) | 149 (44.5) | 120 (35.8) | 121 (36.1) | 109 (32.4) | |
| Previous smoker | 410 (29.1) | 86 (25.7) | 113 (33.7) | 100 (29.9) | 92 (27.4) | |
| None | 476 (33.7) | 100 (29.9) | 102 (30.4) | 114 (34.0) | 135 (40.2) | |
| Coronary artery disease | 255 (18.1) | 28 (8.4) | 47 (14.0) | 66 (19.7) | 100 (29.8) | |
| Cerebrovascular accident | 100 (7.1) | 18 (5.4) | 21 (6.3) | 21 (6.3) | 32 (9.5) | |
| Dialysis | 20 (1.4) | 1 (0.3) | 2 (0.6) | 5 (1.5) | 11 (3.3) | |
| Peripheral artery disease | 27 (1.9) | 3 (0.9) | 3 (0.9) | 7 (2.1) | 13 (3.9) | |
| LLT at Visit 1 ( n / N ), n (%) | ||||||
| Statin | 329/333 (98.8) | 322/328 (98.2) | 314/329 (95.4) | 294/333 (88.3) | ||
| Intensive statin | 59/333 (17.7) | 18/328 (5.5) | 26/329 (7.9) | 17/333 (5.1) | ||
| Ezetimibe | 37/333 (11.1) | 19/329 (5.8) | 14/329 (4.3) | 14/333 (4.2) | ||
| Change in LDL-C from first measurement after hospitalization to Visit 1 | ||||||
| Number | 335 | 335 | 335 | 336 | ||
| mg/dL, mean (SD) | −57.6 (7.29) | −40.5 (4.30) | −23.8 (5.94) | 12.7 (24.44) |
§ Evaluated patients with available and changed LDL-C measurement at Visit 3.
# At first measurement after hospitalization.
Visit 1 was within 14 days of hospitalization for ACS.
ACS, acute coronary syndrome; BMI, body mass index; CV, cardiovascular; eGFR, estimated glomerular filtration rate; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; LLT, lipid-lowering therapy; SD, standard deviation; STEMI, ST-segment- elevation myocardial infarction; UA, unstable angina.