Fig.8. Eicosanoids impaired endothelial function in non-diabetic mice.
(A) Incubation with PGE 2 significantly impaired endothelium-dependent vasodilation, as determined by the response to Ach. (B) TXB 2 tended to impair endothelial function although it did not reach statistical significance. (C) PA significantly impaired endothelial function. Endothelium-independent vascular function, as measured in response to SNP, did not differ across these groups ( n =8–9 per group). ＊ P ＜0.05 vs. NT (non-treatment). All values are mean±SEM.