Table 1.

Summary of STAUl expression profile and function in various cancers

Cancer	Cell line	STAUl expression	Cell function	mRNA metabolism	Observation	Impact
Colorectal cancer	HCT116, LS174T, HT-29	N/A	Cell cycle control, proliferation, apoptosis	Ribosome assembly, protein translation, SMD	Modulation of STAU1 expression impacts cell survival [18, 98]	Tumor promoting or tumor inhibiting
Osteosarcoma	U2OS	N/A	Cell cycle control and proliferation	N/D	An ectopic expression of STAUl impairs proliferation [18]	N/D
Glioblastoma	U87, U251	N/A	Tumor growth and metastasis	SMD	Increased SMD of RAX2 inhibits glioblastoma progression [75]	Tumor inhibiting
Gastric cancer	SGC7901, BGC823	N/A	Cell proliferation, in vitro migration and invasion	SMD	STAUl silencing reduces cell prolifera tion [12]	Tumor promoting
Embryonal rhabdomyosarcoma	RD	Increased (> 2.5-fold)	Cell proliferation, in vitro migration and  invasion, tumorigenesis	Protein translation	STAUl silencing reduces ERMS progression [32]	Tumor promoting
Alveolar rhabdomyosarcoma	RH30, RH41	Increased (~ twofold)	Apoptosis, in vitro migration and invasion, tumorigenesis	Autophagy	STAUl silencing reduces ARMS progression via autophagy inhibition [32, 33]	Tumor promoting
Prostate cancer	LNCaP, DU145, PC3	Increased (> 2000-fold)	Cell proliferation, in vitro migration and invasion	N/D	STAU1 silencing reduces prolifera tion or metastasis of prostate cancer cells [31]	Tumor promoting
Neuroblastoma	SH-SY5Y, neuro-2a	N/A	Apoptosis, Neural growth, differentiation, dendrite formation and morphology,	mRNA localization, alternative splicing, SMD	STAUl silencing partially blocks neural cell differentiation and promotes apoptosis [28, 69, 86]	Tumor promoting or tumor inhibiting
Cervical cancer	HeIa	N/A	Cell migration	SMD	STAU1 depletion promotes cell migration in wound healing assay [91]	Tumor inhibiting

N/A Not Available, N/D Not Determined