Table 3.
Summary of findings: Sedative compared with a different sedative for children needing dental care
| Patient or population: children needing dental care Setting: hospital Intervention: sedative Comparison: placebo | |||
|---|---|---|---|
| Outcomes | Number of participants (studies) | Certainty of the evidence (GRADE) | Comments |
|
Any behavioural score Chloral hydrate/hydroxyzine versus |
235 (6) |
⊕ ⊝ ⊝ ⊝ VERY LOW1 |
Very few studies evaluated the same intervention and comparisons. No studies that did evaluate similar interventions and comparisons found the same effect. There is insufficient evidence to draw any conclusions |
|
Any behavioural score Chloral hydrate/promethazine versus |
24 (1) |
⊕ ⊝ ⊝ ⊝ VERY LOW1 |
|
|
Any behavioural score Dexmedetomidine versus |
160 (3) |
⊕ ⊝ ⊝ ⊝ VERY LOW1 |
|
|
Any behavioural score Ketamine vs |
569 (9) |
⊕ ⊝ ⊝ ⊝ VERY LOW1 |
|
|
Any behavioural score Ketamine/midazolam vs |
175 (4) |
⊕ ⊝ ⊝ ⊝ VERY LOW1 |
|
|
Any behavioural score Midazolam (oral) vs |
654 (7) |
⊕ ⊝ ⊝ ⊝ VERY LOW1 |
|
|
Any behavioural score Midazolam (intravenous) vs |
70 (2) |
⊕ ⊝ ⊝ ⊝ VERY LOW1 |
|
|
Any behavioural score Midazolam (rectal) vs |
90 (1) |
⊕ ⊝ ⊝ ⊝ VERY LOW1 |
|
|
Any behavioural score Sevoflurane vs |
1140 (3) |
⊕ ⊝ ⊝ ⊝ VERY LOW1 |
|
GRADE Working Group grades of evidence
High certainty: we are very confident that the true effect lies close to that of the estimate of the effect
Moderate certainty: we are moderately confident in the effect estimate: the true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different
Low certainty: our confidence in the effect estimate is limited: the true effect may be substantially different from the estimate of the effect
Very low certainty: we have very little confidence in the effect estimate: the true effect is likely to be substantially different from the estimate of effect
1Downgraded for risk of bias, inconsistency and/or imprecision