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. 2021 Nov 2;78(23):7899–7914. doi: 10.1007/s00018-021-03967-8

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — A Upper traces show representative I_hERG records elicited by protocol shown as lower traces. Tail currents were elicited at −40 mV following depolarizing pulses to +40 mV for differing time periods between 50 and 1100 ms. Left hand panel shows recordings in control solution and right-hand panel contains recordings from the same cell during exposure to 30 µM phenanthrene. B Plot of mean fractional block of I_hERG tail by 30 µM phenanthrene against command pulse duration (n = 5). A monoexponential fit to these data (from each experiment) gave an inhibition time constant (τ_inhib) of 130.2 ± 15.4 ms. A one-way ANOVA showed an overall significance in the time dependence of inhibition (p < 0.0001), with (Bonferroni) post hoc testing showing that inhibition following pulses of up to 200 ms in duration was significantly different from all durations of 500 ms and longer (p < 0.05 or less for all comparisons)