Table 2.

Neurophysiological results in CANVAS cohorts

	Smulewicz et al. 2011 n = 18	Wu et al. 2014 n = 26	Smulewicz et al. 2015 n = 14	Cazzato et al. 2015 n = 4	Burke et al. 2018 n = 5	Infante et al. 2018 n = 4	Total
Upper limb snaps	15/18 absent 3/18 NR	21/26 absent 4/26 reduced 1/26 normal	14/14 absent	4/4 reduced	3/5 absent 2/5 reduced	4/4 absent	Absent: 57/68 (84%) Reduced: 10/68 (15%) Normal: 1/68 (< 1%)
Lower limb snaps	15/18 absent 3/18 NR	24/26 absent 2/26 reduced	14/14 absent	3/4 absent 1/4 reduced	4/5 absent 1/5 reduced	3/4 absent 1/4 reduced	Absent: 63/68 (93%) Reduced: 5/68 (7%)
CMAP	12/18 normal 6/18 reduced	19/26 normal 7/26 reduced	14/14 normal	4/4 normal	4/5 normal 1/5 reduced	4/4 normal	Normal: 57/71 (80%) Reduced: 14/71 (20%)
DML	12/18 normal 6/18 mildly prolonged	–	10/14 normal 4/14 mildly prolonged	–	–	4/4 normal	Normal: 26/36 (72%) Mildly prolonged: 10/36 (28%)
Motor NCV	12/18 normal 6/18 mildly slowed	–	14/14 normal	4/4 normal	–	4/4 normal	Normal: 34/40 (85%) Mildly slowed: 6/40 (15%)
F-wave latency	9/18 normal 5/18 mildly prolonged 4/18 NR	–	–	–	5/5 normal	4/4 normal	Normal: 18/23 (78%) Mildly prolonged: 5/23 (22%)
Tibial H-reflex	–	–	11/14 absent 3/14 retained	–	–	–	Retained: 3/14 (21%)
Blink reflex	–	–	12/14 abnormal 2/14 normal	–	–	–	Abnormal: 12/14 (86%)
CSP	–	–	7/14 abnormal 7/14 normal	–	–	–	Abnormal: 7/14 (50%)

SNAPs sensory nerve action potential, CMAP compound motor action potential, DML distal motor latency, NCV nerve conduction velocity, CSP cutaneous silent period, NR not recorded