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. 2021 Oct 13;78(23):7505–7518. doi: 10.1007/s00018-021-03959-8

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — hCNT1 is decreased in tumors vs healthy adjacent tissue in colorectal cancer (CRC) and pancreatic ductal adenocarcinoma (PDAC). A hCNT1 mRNA levels in CRC (n = 17) or PDAC (n = 9) clinical samples, comparing tumor and normal adjacent tissue. Statistical significance was determined with Student’s t test. B Immunofluorescence images of hCNT1 protein (green) in four, paired, independent clinical samples of tumor and normal adjacent CRC and PDAC tissue. hCNT1 was detected using a polyclonal anti-CNT1 antibody. All the images were obtained under the same magnification. Scale bars, 75 µm. C Patient and tumor samples characteristics, including the number of samples in each category. s.d., standard deviation; RS, resectable; LA, locally advanced