TABLE 1.
Analysis of in vivo cardiac size and function by echocardiography in FHL2-deficient mice at basal level and 7 days following TAC
| Mouse group | Avg ± SDa
|
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Body wt (mg) | Heart rate (beats/min) | IVS (mm) | PW (mm) | LVEDD (mm) | LVESD (mm) | FS% | Vcf (circumferences/s) | PG (mm of Hg) | Heart wt/ body wt | |
| Wild type | ||||||||||
| Basal (n = 9) | 36.5 ± 5.4 | 488 ± 40 | 0.70 ± 0.08 | 0.73 ± 0.08 | 3.63 ± 0.53 | 2.12 ± 0.56 | 42.4 ± 8.9 | 7.69 ± 1.83 | ||
| After TAC (n = 9) | 34.5 ± 4.32 | 425 ± 38 | 0.94 ± 0.11b | 1.00 ± 0.15b | 3.10 ± 0.32c | 1.51 ± 0.31c | 51.5 ± 8.2c | 9.18 ± 1.25 | 67 ± 28 | 0.41 ± 0.07 |
| Homozygous | ||||||||||
| Basal (n = 6) | 34.5 ± 6.5 | 414 ± 63 | 0.71 ± 0.04 | 0.70 ± 0.11 | 3.91 ± 0.45 | 2.45 ± 0.46 | 37.6 ± 6.2 | 7.16 ± 1.01 | ||
| After TAC (n = 6) | 34.2 ± 7.08 | 427 ± 46 | 0.90 ± 0.24d | 0.88 ± 0.25d | 3.04 ± 0.43d | 1.66 ± 0.5d | 46.0 ± 12.2d | 8.05 ± 2.74 | 85 ± 47 | 0.38 ± 0.06 |
a
IVS, interventricular wall thickness; PW, left ventricular posterior wall thickness; LVEDD, end-diastolic left ventricular dimension; LVESD, end-systolic left ventricular dimension; FS%, left ventricular percent fractional shortening; Vcf, velocity of circumferential fiber shortening; PG, pressure gradient across the aortic constriction.
b
P < 0.001, wild type after TAC versus basal.
c
P < 0.05, wild type after TAC versus basal.
d
P < 0.05, homozygous after TAC versus basal.