Table 1.
CpG sites significantly associated with CIMT in discovery panel and replication study
| CpG site | Position | Gene | Discovery Panel | Replication study | Combined analysis | |||
|---|---|---|---|---|---|---|---|---|
| Beta | p value | Beta | p value | Beta | p value | |||
| cg05575921* | Chr5:373378 | AHRR | − 0.02 | 3.5 × 10−8 | − 0.07 | 0.005 | − 0.03 | 3.17 × 10−9 |
| cg05575921** | Chr5:373378 | AHRR | − 0.02 | 2.2 × 10−8 | − 0.08 | 0.004 | − 0.03 | 1.9 × 10−9 |
*First model: BETA ~ Ln(cIMT) + age + sex + tech cov + cell counts + smoking status (+ study specific)
**Second model: BETA ~ Ln(cIMT) + age + sex + tech cov + cell counts + smoking status (+ study specific) + BMI + HDLC/TC ratio + SBP + antihypertensive + lipid lowering + pDM.