Table 2.
Mendelian randomization analysis on the effect of cardiovascular risk factors on cg05575921
| Method | Estimate (95% CI) | p value | p value heterogeneity (IVW) |
|---|---|---|---|
| Smoking (no. cigarettes/day) → cg05575921 | |||
| IVW | − 0.04 (− 0.09 to 0.06) | 0.0001 | 0.9 |
| MR-Egger | − 0.06 (− 0.39 to −0.27) | 0.08 | – |
| MR-Egger (intercept) | 0 | 0.5 | – |
| Weighted median | − 0.04 (− 0.18 to 0.05) | 0.08 | – |
| LDL-cholesterol (mg/dl−1) → cg05575921 | |||
| IVW | 0.002 (− 0.02 to 0.02) | 0.4 | 0.9 |
| MR-Egger | 0.0001 (− 0.05 to 0.02) | 0.9 | – |
| MR-Egger (intercept) | 0 | 0.5 | – |
| Weighted median | 0.003 (− 0.05 to 0.01) | 0.4 | – |
| Systolic blood pressure (mm Hg) → cg05575921 | |||
| IVW | − 0.001 (− 0.005 to 0.003) | 0.06 | 0.4 |
| MR-Egger | 0.004 (− 0.01 to 0.01) | 0.04 | – |
| MR-Egger (intercept) | − 0.001 | 0.006 | – |
| Weighted median | − 0.001 (− 0.008 to 0.004) | 0.2 | – |
| Diastolic blood pressure (mm Hg) → cg05575921 | |||
| IVW | − 0.001 (− 0.008 to 0.003) | 0.3 | 0.8 |
| MR-Egger | 0.001 (0.026–0.07) | 0.8 | – |
| MR-Egger (intercept) | 0 | 0.6 | – |
| Weighted median | − 0.001 (− 0.01 to 0.007) | 0.6 | – |
| Pulse pressure (mm Hg) → cg05575921 | |||
| IVW | 0.0001 (0.0001–0.002) | 0.9 | 0.9 |
| MR-Egger | 0.0001 (0.0003–0.003) | 0.8 | – |
| MR-Egger (intercept) | 0 | 0.8 | – |
| Weighted median | − 0.001 (− 0.002 to 0.02) | 0.5 | – |
| Fasting glucose (mmol/l) → cg05575921 | |||
| IVW | − 0.01 (− 0.2 to 0.17) | 0.3 | 0.6 |
| MR-Egger | 0.003 (0.005 to 0.008) | 0.9 | – |
| MR-Egger (intercept) | 0 | 0.6 | – |
| Weighted median | − 0.02 (− 0.3 to 0.2) | 0.3 | – |
| BMI (kg/m2) → cg05575921 | |||
| IVW | − 0.009 (− 0.002 to 0.034) | 0.07 | 0.9 |
| MR-Egger | 0.001 (0.004− 0.008) | 0.9 | |
| MR-Egger (intercept) | 0 | 0.4 | |
| Weighted median | − 0.009 (− 0.002 to 0.04) | 0.2 |
BMI body mass index, CAD coronary artery disease, cIMT carotid intima media thickness, IVW inverse variance weighted, LDL low-density lipoprotein