Table 3.

Mendelian randomization on the effect of cg05575921 on coronary artery disease (CAD), cIMT and stroke

Method	Estimate (95% CI)	p value	p value heterogeneity (IVW)
cg05575921 → CAD
IVW	0.5 (− 0.03 to 0.9)	0.06	0.8
cg05575921 → cIMT (mm)
IVW	0.06 (0.01–0.1)	0.01	0.2
MR-Egger	− 0.04 (− 0.2 to 0.09)	0.5	–
MR-Egger (intercept)	0.003	0.1	–
Weighted median	0.07 (0.008–0.13)	0.02	–
cg05575921 → Stroke
IVW	0.8 (0.23–1.47)	0.007	0.8
MR-Egger	0.3 (− 1.3–1.9)	0.7	–
MR-Egger (intercept)	0.02	0.5	–
Weighted median	0.9 (0.17–1.58)	0.01	–