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. 2021 Nov 25;16:3217–3228. doi: 10.2147/COPD.S338359

Table 3.

Risk Factors for Lung Development at Different Life Stages

The Stage of Life The Risk Factors for Lung Function
Genetics α1-antitrypsin deficiency
ADAM33, SOX5, TNS1
Antenatal period Maternal smoking
LBW/VLBW, Preterm birth
Maternal nutrition
Mode of delivery Vitamin D deficiency
Childhood Childhood smoking
Air Pollution
Childhood respiratory infections
Childhood asthma Manual working class and overcrowding

Abbreviations: LBW, low birth weight; VLBW, very low birth weight.