Table 4.

Stratification Analyses of the Primary Outcome

GOLD Group at Baseline	Group A/B N =33			Group C/D N = 67
	Intervention	Control	p-value	Intervention	Control	p-value
	N = 16	N = 17		N = 29	N = 38
Change in annual exacerbation frequency
Total population	0.0 (0.0–1.0)	0.0 (0.0–0.0)	0.204	−2.0 (−5.0 – −0.5)	−1.0 (−2.3–1.0)	0.020
Population attending	0.0 (0.0–1.0)	0.0 (0.0–0.0)	0.007	−3.0 (−5.3 – −1.0)	−0.5 (−2.0–1.0)	0.001
6-month follow-up
GOLD stage at baseline	Stage 1/2 N =31			Stage 3/4 N =47
	Intervention	Control	p-value	Intervention	Control	p-value
	N = 20	N = 11		N = 17	N = 30
Change in annual exacerbation frequency
Total population	−1.0 (−3.0–0.0)	0.0 (−2.0–0.0)	0.317	−1.0 (−5.0–0.0)	−1.0 (−2.3–1.0)	0.288
Population attending	−1.0 (−3.8–0.0)	0.0 (−2.0–2.0)	0.166	−6.0 (−3.0–0.0)	−1.0 (−2.0–1.0)	0.046
6-month follow-up
Number of periodontal pockets > 5 mm at baseline	Zero N = 47			≥1 N = 54
	Intervention	Control	p-value	Intervention	Control	p-value
	N = 20	N = 27		N = 25	N = 29
Change in annual exacerbation frequency
Total population	−1.0 (−3.8–0.0)	0.0 (−1.0–1.0)	0.047	0.0 (−2.5–0.5)	−1.0 (−2.0–0.0)	0.853
Population attending	−1.5 (−4.3–0.0)	0.0 (−1.0–1.0)	0.007	0.0 (−3.0–1.0)	0.0 (−1.3–1.0)	0.865
6-month follow-up

Notes: Difference between the intervention and control groups in change of annual exacerbation frequency between baseline and 12-month follow-up. Analyses used Mann–Whitney-U test, stratified by GOLD groups and GOLD stages and number of periodontal pockets >5 mm at baseline. Values are presented as median (interquartile ranges).

Abbreviation: GOLD, Global Initiative for Obstructive Lung Disease.