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. Author manuscript; available in PMC: 2023 Jan 28.
Published in final edited form as: Cancer Lett. 2021 Oct 30;525:108–114. doi: 10.1016/j.canlet.2021.10.035

Figure 1. Single-cell analysis of prostate epithelial heterogeneity.

Figure 1.

(A) Schematic model of prostate lobes, with the urethral rhabdosphincter partially removed to show the distribution of luminal epithelial populations as indicated. (B) t-distributed stochastic neighbor embedding (tSNE) plot of 5,288 cells from an aggregated dataset of two normal mouse prostates. (C) Immunofluorescence staining of a mouse dorsal prostate lobe, showing proximal luminal cells marked with Ppp1r1b and a medial border between proximal and distal luminal cells. (D) Heatmap visualization of transcriptional Wasserstein distances (also known as earth mover’s distances); this metric corresponds to transcriptional differences between populations, where less distance indicates transcriptional similarity, and greater distance indicates dissimilarity) between human and mouse prostate populations. Adapted from [8].