Figure 6.

HLA-G residues that are polymorphic or may influence HLA-G function, considering known allotypes detected in 4642 samples from across the world and new allotypes that have occurred at least twice. Polymorphic residues are marked in shades of gray. Important residues for the HLA-G function are marked in other colors. For allotypes with premature stop-codons, there is no amino acid indication after the frameshift mutation. In red, the Cysteine responsible for dimer formation. In green, the Methionine and Glutamine that interact with KIR2DL4. In purple and yellow, the important residues for ILT-2 and ILT-4 interaction. In blue, the motif DQTQDVE, which interacts with the TCD8 receptor.