Table 3.
Synonymous and nonsynonymous nucleotide substitution test of neutrality, positive, and purifying selection for analysis over 77 HLA-G sequences defined by exon mutations, in 4640 samples from 88 different populations.
| dN/dS neutrality test | Number of sequences | Number of codons | HA = neutrality (dN ≠ dS)* | HA = positive selection (dN > dS) | HA = purifying selection (dN < dS)* |
|---|---|---|---|---|---|
| Exon 1 | 11 | 24 | − 0.8576, P = 0.3928 | − 0.9059, P = 1.0000 | 0.8804, P = 0.1902 |
| Exon 2 | 19 | 90 | − 1.1546, P = 0.2505 | − 1.1160, P = 1.0000 | 1.1258, P = 0.1312 |
| Exon 3 | 20 | 92 | − 0.6806, P = 0.4973 | − 0.6930, P = 1.0000 | 0.6790, P = 0.2491 |
| Exon 4 | 17 | 92 | − 1.0288, P = 0.3056 | − 1.007, P = 1.0000 | 0.9609, P = 0.1692 |
| Exon 5 | 10 | 39 | − 1.5091, P = 0.1338 | − 1.3480, P = 1.0000 | 1.4232, P = 0.0786 |
| All exons | 77 | 339 | − 2.5808, P = 0.0110 | − 2.5069, P = 1.0000 | 2.6134, P = 0.0050 |
| Exons 2 and 3 | 39 | 182 | − 1.3036, P = 0.1948 | − 1.2308, P = 1.0000 | 1.2635, P = 0.1044 |
| Exons 2, 3, and 4 | 55 | 274 | − 1.7453, P = 0.0834 | − 1.7482, P = 1.0000 | 1.6929, P = 0.0465 |
*Significant P-values are marked in boldface.