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. 2021 Nov 29;12(12):1116. doi: 10.1038/s41419-021-04406-z

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — A Confocal microscopy image of the internalization of fluorescently labeled GC exosomes in GCSCs. B Effects of GC exosomes on lncFERO levels in GCSCs (n = 3). C–F Exo-lncFERO derived from GC cells suppresses erastin-induced ferroptosis in GCSCs. GC exo-lncFERO decreases erastin-induced cell death (C) (n = 3), inhibits lipid ROS accumulation (D) (n = 3), and reduces abnormal increases in MMP (E, F) (n = 3). G Effects of erastin and exo-lnc-FERO on sphere formation of GCSCs (n = 3). **p < 0.01.