Table 1:
Summary of key study endpoints. N = number of paired data points. WL = whole lung; CC60-90 = cough assisted clearance between 60-90 min; C/P = central/peripheral; CL = central lung; PL = peripheral lung; FeNO = fractional exhaled NO. Listed p values are not corrected for multiple comparisons.
| Variable | N | Baseline | 1-month | Paired t-test P-values |
|---|---|---|---|---|
| Sweat Chloride - mEq/L | 24 | 99.4 ± 9.0 | 81.6 ± 12.0 | 1.8E-07 |
| FEV1 - L | 25 | 2.53 ± 0.92 | 2.55 ± 0.96 | 0.70 |
| FVC - L | 25 | 3.34 ± 1.06 | 3.39 ± 1.06 | 0.42 |
| FEV1 - % pred | 25 | 77.2 ± 24.4 | 77.1 ± 23.9 | 0.98 |
| FVC - % pred | 24 | 86.9 ± 18.4 | 87.3 ± 15.8 | 0.75 |
| FeNO | 21 | 11.2 ± 6.5 | 12.3 ± 8.8 | 0.40 |
| LCI2.5% | 21 | 12.1 ± 5.3 | 11.8 ± 4.7 | 0.56 |
| WL_Ave60 % | 25 | 11.9 ± 10.4 | 10.6 ± 8.1 | 0.45 |
| WL_Ave90 % | 25 | 13.9 ± 11.4 | 13.2 ± 8.1 | 0.70 |
| WL_24hr % | 25 | 28.7 ± 18.2 | 30.2 ± 16.3 | 0.76 |
| CC60-90 %/min | 25 | 0.07 ± 0.24 | 0.21 ± 0.31 | 0.02 |
| Deposition C/P ratio | 25 | 2.37 ± 0.91 | 2.19 ± 0.65 | 0.26 |
| Deposition skew | 25 | 2.08 ± 1.65 | 1.76 ± 1.14 | 0.11 |
| CL_Ave60 % | 25 | 16.4 ± 14.7 | 16.5 ± 11.0 | 0.98 |
| CL_Ave90 % | 25 | 19.6 ± 15.6 | 20.5 ± 11.0 | 0.70 |
| PL_Ave60 % | 25 | 7.1 ± 5.9 | 5.7 ± 7.3 | 0.35 |
| PL_Ave90 % | 25 | 8.1 ± 6.4 | 7.3 ± 7.3 | 0.58 |