TABLE 1.
Sociodemographic characteristics of the pediatric cohort by concordance of parental preferences for receiving secondary findings
| Discordant parental preferences N = 12 | Concordant parental preferences N = 330a | p value | |
|---|---|---|---|
| Median maternal age at enrollment (IQR)-weeks | 33.5 (30–37) | 34 (28–39) | 0.81 |
| Median paternal age at enrollment (IQR)-weeks | 37.5 (33–42) | 37 (31–44) | 0.97 |
| Maternal race/ethnicity | 0.27 | ||
| American Indian/Alaska Native | 1 (8.3) | 2 (0.6) | |
| Asian | 1 (8.3) | 34 (10.3) | |
| Native Hawaiian/Pacific islander | 0 (0) | 4 (1.2) | |
| Non-hispanic Black | 0 (0) | 11 (3.3) | |
| Non-hispanic White | 3 (25.0) | 72 (21.8) | |
| Hispanic or Latina | 5 (41.7) | 143 (43.3) | |
| Unknown | 1 (8.3) | 41 (12.4) | |
| Multiracial | 1 (8.3) | 23 (7.0) | |
| Paternal race/ethnicity | 0.97 | ||
| American Indian/Alaska Native | 0 (0) | 4 (1.2) | |
| Asian | 1 (8.3) | 28 (8.5) | |
| Native Hawaiian/Pacific islander | 0 (0) | 4 (1.2) | |
| Non-hispanic Black | 0 (0) | 13 (3.9) | |
| Non-hispanic White | 4 (33.3) | 81 (24.5) | |
| Hispanic or Latino | 5 (41.7) | 133 (40.3) | |
| Unknown | 1 (8.3) | 52 (15.7) | |
| Multiracial | 1 (8.3) | 15 (4.5) | |
| Highest level of maternal education | 0.99 | ||
| Less than high school | 3 (25.0) | 69 (20.9) | |
| High school diploma or equivalent | 3 (25.0) | 74 (22.4) | |
| Some college or Associate’s degree | 3 (25.0) | 75 (22.7) | |
| Bachelor’s degree | 1 (8.3) | 37 (11.2) | |
| Professional or graduate degree | 1 (8.3) | 27 (8.2) | |
| Unknown | 1 (8.3) | 48 (14.5) | |
| Highest level of paternal education | 0.17 | ||
| Less than high school | 2 (16.7) | 61 (18.5) | |
| High school diploma or equivalent | 1 (8.3) | 72 (21.8) | |
| Some college or Associate’s degree | 0 (0) | 53 (16.1) | |
| Bachelor’s degree | 2 (16.7) | 29 (8.8) | |
| Professional or graduate degree | 0 (0) | 19 (5.8) | |
| Unknown | 7 (58.3) | 96 (29.1) | |
| Maternal relationship status | 0.32 | ||
| Single | 1 (8.3) | 20 (6.1) | |
| Married | 6 (50.0) | 189 (57.3) | |
| In a relationship | 2 (16.7) | 66 (20.0) | |
| Divorced or separated | 2 (16.7) | 13 (3.9) | |
| Widowed | 0 (0) | 0 (0) | |
| Unknown | 1 (8.3) | 42 (12.7) | |
| Use of interpreter | 6 (50.0) | 132 (40.0) | 0.49 |
Note: Proportions presented as N (%). Continuous variables presented as median (IQR).
Abbreviation: IQR, interquartile range.
a
Excluding families in which duo or proband only exome sequencing was performed.