Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Nov 29;11:23041. doi: 10.1038/s41598-021-02441-6

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Building a trajectory of chromatin reorganization associated with breast cancer progression. (a) Representative crops of Hoescht -stained tissue biopsy images of different stages of breast cancer. (b) Prediction accuracy of the linear discriminant classifier on the test dataset. Error bars denote the standard error of classification in across 5 cross validation tests. (c) Diffusion Map of nuclei from various stages of cancer. Each dot represents one cell and the color code is displayed as an inset. (d) Heatmap depicting the branch-wise changes to representative nuclear morphology and chromatin organization features. The color code is indicated near the bottom. Note that each column represents a single cell. The column-side color bar at the bottom of the heatmap represents the stage of cancer.