Table 1.
Comparison of demographic characteristics between the T2DM and control groups
| Characteristics | Control(n = 74) | T2DM(n = 74) | p values |
|---|---|---|---|
| Age(years) | 46.2 ± 6.1 | 48.1 ± 6.5 | 0.66 |
| Gender (Male/female) | 31/38 | 33/41 | 0.511 |
| BMI(Kg/m2) | 27.9 ± 4.0 | 29.3 ± 5.1 | 0.082 |
| Waist/hip ratio | 0.88 ± 0.07 | 1.1 ± 0.1 | <0.001 |
| Systolic BP (mmHg) | 119 ± 14 | 125 ± 14 | 0.01 |
| Diastolic BP (mmHg) | 75 ± 13 | 83 ± 10 | <0.001 |
| FBS (mg/dl) | 93.0 ± 12.5 | 163.3 ± 80.7 | <0.001 |
| HbA1c (%) | 4.6 ± 0.66 | 7.4 ± 2.3 | <0.001 |
| Insulin (μIU/dl) | 7.0 ± 5.2 | 8.2 ± 7.8 | 0.248 |
| HOMA-IR | 1.7 ± 1.4 | 3.8 ± 3.3 | 0.002 |
| HOMA-B (%) | 91.4 ± 64.4 | 47.4 ± 53.3 | <0.001 |
| QUICKI | 0.375 ± 0.048 | 0.342 ± 0.037 | <0.001 |
| TG (mg/dl) | 155 ± 83 | 166 ± 65 | 0.61 |
| TC (mg/dl) | 189 ± 38 | 166 ± 44 | 0.002 |
| LDL-C (mg/dl) | 107 ± 26 | 92 ± 29 | 0.002 |
| HDL-C (mg/dl) | 47 ± 10 | 46 ± 11 | 0.372 |
| TG/HDL-C ratio | 3.5 ± 2.2 | 3.9 ± 1.7 | 0.279 |
| Albumin (g/dl) | 4.6 ± 0.5 | 4.4 ± 0.4 | 0.027 |
| Uric acid (mg/dl) | 5.3 ± 1.2 | 5.2 ± 1.5 | 0.181 |
| TAC (nmol/lit) | 1155± 1255 | 999 ±256 | <0.001 |
| Trp (mmol/lit) | 69.5 ± 17.8 | 62.3 ± 28.1 | 0.168 |
| Kyn (mmol/lit) | 0.88 ± 0.56 | 1.15 ± 0.44 | 0.08 |
| KTR | 0.013 ± 0.006 | 0.022 ±0.014 | 0.028 |
BMI Body mass index, BP blood pressure, FBS fasting blood sugar, HOMA-IR Homeostatic model assessment of insulin resistance, QUICKI quantitative insulin sensitivity check, HOMA-B homeostatic model assessment to quantify beta-cell function, TG Triglyceride, TC Total cholesterol, LDL-C Low density lipoprotein cholesterol, HDL-C High density lipoprotein cholesterol, Trp Tryptophan, Kyn Kynurenine, KTR Kynurenine/Tryptophan ratio. Data were analyzed using Student T test or Mann-Whitney-U test. p < 0.05 was considered as significant difference among groups