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. 2021 Nov 29;12:6951. doi: 10.1038/s41467-021-27289-2

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Top-ranking differential pathways. Graph illustrates –log₁₀(p-values) and false discovery rates (FDRs), with bars colored by FDR, from Limma Roast’s Mixed statistic⁸⁷ (which is one-sided) adjusted with FDRs. b Phospholipid biosynthesis network. Nodes are colored by between-group z-score, whereas unmeasured nodes are colored dark gray. Orientation of triangle also indicates the directionality of regulation. Connections are from the Pathway Commons network. Source data are provided as a Source Data file.