. 2021 Nov 29;11:23080. doi: 10.1038/s41598-021-01660-1

Box 5.

Concentrations of biomarkers as a function of membrane affinity to fibrinogen (K), Qb, and t.

$C 5 a = 1.074 E^{5} - 8533.82 \cdot K [kcal / mol] + 102.68 \cdot Qb [mL / min] - 304.16 \cdot t [min]$	(33)
$P r o p e r d i n = 1.12 E^{7} + 7680.83 \cdot Qb [mL / min] - 42987.50 \cdot t [min] + 713.90 \cdot Qb [mL / min] \cdot t [min]$	(34)
$C 5 b 9 = - 431.49 - 380.40 \cdot K [kcal / mol] - 79.40 \cdot Qb [mL / min] - 18.27 \cdot t [min] - 14.87 \cdot K [kcal / mol] \cdot Qb [mL / min] + 0.22 \cdot Qb [mL / min] \cdot t [min]$	(35)
$S e r p i n = 1.59 E^{8} + 4.58 E^{5} \cdot Qb [mL / min] - 1.78 E^{6} \cdot t [min] - 17722.05 \cdot Qb [mL / min] \cdot t [min]$	(36)
$I L 1 β = 3.20 + 0.069 \cdot K [kcal / mol] - 0.00082 \cdot Qb [mL / min] - 0.009472 \cdot t [min] + 0.000052 \cdot Qb [mL / min] \cdot t [min]$	(37)
$I L 1 α = 1.49 + 0.025 \cdot K [kcal / mol] - 0.0017 \cdot Qb [mL / min] + 0.17 \cdot t [min] + 0.026 \cdot K [kcal / mol] \cdot t [min] - 7.9 E^{5} \cdot Qb [mL / min] \cdot t [min]$	(38)
$I L 6 = 1.44 - 0.0071 \cdot K [kcal / mol] + 0.023 \cdot Qb [mL / min] - 0.0073 \cdot t [min] + 0.0033 \cdot K [kcal / mol] \cdot Qb [mL / min]$	(39)
$v W F = - 495.72 - 165.44 \cdot K [kcal / mol] + 1.48 \cdot Qb [mL / min]$	(40)