TABLE 2.
Forward mutation rates at CAN1 in strains with POL3 missense mutations and/or mutations affecting DNA repair or recombination
| Strain genotypea | Rate of canavanine resistance (10−7 per cell division)b | 95% Confidence interval (10−7 per cell division) |
|---|---|---|
| WT | 2.4 (1) | 2.3–2.9 |
| pol3-ts1 | 14 (6) | 10–18 |
| pol3-ts11 | 10 (4) | 9.4–13 |
| pol3-ts26 | 9.7 (4) | 8.5–11 |
| msh3 | 2.5 (1) | 2.1–3.2 |
| rad52 isolate 1 | 27 (11) | 24–33 |
| rad52 isolate 2 | 29 (12) | 25–40 |
| pol3-ts1 msh3 | 47 (20) | 42–62 |
| pol3-ts1 rad52 | 63 (26) | 48–77 |
| pol3-ts1 msh3 rad52 isolate 1 | 50 (21) | 45–75 |
| pol3-ts1 msh3 rad52 isolate 2 | 42 (18) | 22–48 |
a
Strain names are as follows: RJK160-1 (wild type [WT]), RJK158-3 (pol3-ts1), RJK187-1 (pol3-ts11), RJK223-1 (pol3-ts26), RJK357 (msh3), RJK334 (rad52 isolate 1), RJK335 (rad52 isolate 2), RJK358 (pol3-ts1 msh3), RJK288 (pol3-ts1 rad52), RJK363 (pol3-ts1 msh3 rad52 isolate 1), and RJK381 (pol3-ts1 msh3 rad52 isolate 2).
b
Numbers given in parentheses are fold increase over wild type.