TABLE 5.
Effect of pol3 missense mutations on 33-bp dinucleotide repeat instability
| Strain genotypea | Rate of 5-FOAr (10−6 per cell division)b | 95% Confidence interval (10−6 per cell division) |
|---|---|---|
| WT | 4.3 (1) | 1.6–7.3 |
| pol3-ts1 | 10 (2.3) | 6.3–13 |
| pol3-ts11 | 5.0 (1.2) | 3.3–6.2 |
| pol3-ts26 | 5.6 (1.3) | 2.3–10 |
| msh3 | 200 (47) | 160–310 |
| pol3-ts1 msh3 | 660 (150) | 530–990 |
| pol3-ts1 msh3 rad52 | 240 (55) | 170–350 |
a
Strains containing transformed pSH44 are as follows RJK242-1 (wild type [WT]), RJK166-4 (pol3-ts1), RJK202-3 (pol3-ts11), RJK232-5 (pol3-ts26), LS38-1 (msh3), LS40-1 (pol3-ts1 msh3), and RJK380-1 (pol3-ts1 msh3 rad52).
b
Numbers given in parentheses are fold increase over wild type.