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Model for leukemogenic Notch1 signaling complex. CBF1, transcription factor Su(H)/CBF1; CoR/HDAC, corepressor-histone deacetylase complex; X, molecule capable of binding to Su(H)/CBF1 and ICN1, of which SKIP and LAG-3 are prototypes; CoA/HAT, coactivator-histone acetylase complex.
