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. 2021 Aug 11;20(2):1327–1336. doi: 10.1007/s40200-021-00861-9

Table 2.

Meta-analysis of the association between hyperglycemia and periodontitis in cross-sectional studies according to study characteristics

Overall periodontitis risk No point Sample size Pooled OR (95% CI) Heterogeneity assessment
Model I-squared % Q test P-value of heterogeneity
By Quality assessment
 Moderate 2 11,660 1.85 (0.68, 3.00) Random 85.90 7.08 0.008
 High 15 46,800 1.44 (1.02, 1.87) Random 86.50 106.81  < 0.001
By hyperglycemia definition
 FBS 15 55,755 1.47 (1.04, 1.89) Random 87.60 112.06  < 0.001
 HbA1c 2 2,712 1.87 (1.38, 2.36) Fixed 0.00 0.90 0.343
By dental indices
 PD 9 28,602 1.66 (1.06, 2.26) Random 92.00 104.76  < 0.001
 CAL 3 1,365 1.07 (0.53, 1.61) Fixed 0.00 0.98 0.612
 PD/CAL 5 28,500 1.19 (0.92, 1.45) Fixed 0.00 3.62 0.460
By hyperglycemia—dental indices
 FBS-PD 8 26,120 1.62 (0.95, 2.28) Random 93.10 101.85  < 0.001
 FBS-CAL 3 1,365 1.07 (0.53, 1.61) Fixed 0.00 0.98 0.612
 FBS-PD/CAL 4 28,264 1.18 (0.86, 1.50) Fixed 12.50 3.43 0.330
 HbA1c-PD 2 2,712 1.87 (1.39, 2.37) Fixed 0.00 0.90 0.343